GFR alpha-1/GDNF R alpha-1 Antibody (009) [Allophycocyanin]

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF (1,2). The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently (1-5). GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently (5-7). GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP2-90463APC

• GFR alpha-1/GDNF R alpha-1 Antibodies
• GFR alpha-1/GDNF R alpha-1 ELISA Kits
• GFR alpha-1/GDNF R alpha-1 Lysates
• GFR alpha-1/GDNF R alpha-1 Proteins
• GFR alpha-1/GDNF R alpha-1 Proteins and Enzymes