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GFR alpha-1/GDNF R alpha-1 Antibody (009) [CoraFluor™ 1]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA, IHC
Clone
009
Clonality
Monoclonal
Host
Rabbit
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-90463AF350
Alexa Fluor 405
NBP2-90463AF405
Alexa Fluor 488
NBP2-90463AF488
Alexa Fluor 532
NBP2-90463AF532
Alexa Fluor 594
NBP2-90463AF594
Alexa Fluor 647
NBP2-90463AF647
Alexa Fluor 700
NBP2-90463AF700
Alexa Fluor 750
NBP2-90463AF750
Allophycocyanin
NBP2-90463APC
Biotin
NBP2-90463B
DyLight 350
NBP2-90463UV
DyLight 405
NBP2-90463V
DyLight 488
NBP2-90463G
DyLight 550
NBP2-90463R
DyLight 594
NBP2-90463DL594
DyLight 650
NBP2-90463C
DyLight 680
NBP2-90463FR
DyLight 755
NBP2-90463IR
FITC
NBP2-90463F
HRP
NBP2-90463H
Janelia Fluor 525
NBP2-90463JF525
Janelia Fluor 549
NBP2-90463JF549
Janelia Fluor 646
NBP2-90463JF646
Janelia Fluor 669
NBP2-90463JF669
PE
NBP2-90463PE
PerCP
NBP2-90463PCP
Unconjugated
NBP2-90463-100ul
mFluor Violet 450 SE
NBP2-90463MFV450
mFluor Violet 500 SE
NBP2-90463MFV500
mFluor Violet 610 SE
NBP2-90463MFV610
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GFR alpha-1/GDNF R alpha-1 Antibody (009) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GFR alpha-1/GDNF R alpha-1 (Accession#: AAB86600.1; Met 1-Ser 425).
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
GFRA1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for GFR alpha-1/GDNF R alpha-1 Antibody (009) [CoraFluor™ 1]

  • DKFZp313E1012
  • DKFZp686J0156
  • GDNF family receptor alpha 1
  • GDNF family receptor alpha-1
  • GDNF R alpha-1
  • GDNF receptor alpha-1
  • GDNFRAGFR-ALPHA-1
  • GDNFR-alpha-1
  • GDNFRMGC23045
  • GFR alpha1
  • GFR alpha-1
  • GFRA1
  • GFRa-1
  • GFR-alpha-1
  • Glial cell line-derived neurotrophic factor receptor alpha
  • GPI-linked anchor protein
  • PI-linked cell-surface accessory protein
  • RET ligand 1
  • RET1L
  • RETL1FLJ10561
  • TGF-beta related neurotrophic factor receptor 1
  • TGF-beta-related neurotrophic factor receptor 1
  • TRNR1FLJ31546

Background

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF (1,2). The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently (1-5). GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently (5-7). GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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GFR alpha-1/GDNF R alpha-1 Antibody (009) [CoraFluor™ 1]
Species: Mu
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Bioinformatics

Gene Symbol GFRA1