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Gelsolin/GSN Antibody

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Western Blot: Gelsolin/GSN Antibody [NBP2-55565] - Analysis in human cell line RT-4, human cell line U-251 MG and human plasma.
Western Blot: Gelsolin/GSN Antibody [NBP2-55565] - Analysis in human cell line RT-4, human cell line U-251 MG and human plasma.
Immunohistochemistry-Paraffin: Gelsolin/GSN Antibody [NBP2-55565] - Staining of human liver shows moderate to strong cytoplasmic positivity in Kupffer cells.
Immunohistochemistry-Paraffin: Gelsolin/GSN Antibody [NBP2-55565] - Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in dendritic cells.
Immunohistochemistry-Paraffin: Gelsolin/GSN Antibody [NBP2-55565] - Staining of human cervix, uterine shows moderate to strong cytoplasmic positivity in Langerhans cells.
Immunohistochemistry-Paraffin: Gelsolin/GSN Antibody [NBP2-55565] - Staining of human kidney shows moderate to strong cytoplasmic positivity in cells in tubules.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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Gelsolin/GSN Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: AFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPR
Predicted Species
Mouse (91%), Rat (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GSN
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
  • Western Blot 0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Gelsolin/GSN Recombinant Protein Antigen (NBP2-55565PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Gelsolin/GSN Antibody

  • Actin-depolymerizing factor
  • ADF
  • AGEL
  • Brevin
  • DKFZp313L0718
  • gelsolin (amyloidosis, Finnish type)
  • Gelsolin
  • GSN

Background

Gelsolin is a calcium regulated actin binding protein. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gelsolin/GSN
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NBP2-55565
Gelsolin/GSN Antibody
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Bioinformatics

Gene Symbol GSN