Name: FGL2/Fibroleukin Antibody (6D9)
Brand: Novus Biologicals
SKU: H00010875-M01
Price: 519 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, ELISA, Flow, Func, ICC/IF, IHC, IP
Clone	6D9
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Immunogen	FGL2 (NP_006673, 24 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. NNETEEIKDERAKDVCPVRLESRGKCEEAGECPYQVSLPPLTIQLPKQFSRIEEVFKEVQNLKEIVNSLKKSCQDCKLQADDNGDPGRNGLLLPSTGAPG
Specificity	FGL2 (6D9)
Isotype	IgG2a Kappa
Clonality	Monoclonal
Host	Mouse
Gene	FGL2
Purity	Protein A purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer	In 1x PBS, pH 7.4
Preservative	No Preservative
Purity	Protein A purified

Publications using H00010875-M01	Applications	Species
Cherny, I;Hasin, P;Philosoph, LK;Shahal-Zimra, Y;Gurion, R;Rabizadeh, E; Presence and activity of Fibrinogen like protein 2 in platelets PloS one 2023-05-18 [PMID: 37200306]
Lianjing H, Di Z, Ying X et al. FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-?B mediated endothelial oxidative stress. Front Immunol. 2023-03-27 [PMID: 37051251]
Ran T, Meiwen H, Wei Y et al. Fibrinogen-like protein 2 promotes proinflammatory macrophage polarization and mitochondrial dysfunction in liver fibrosis. Int Immunopharmacol. 2023-03-04 [PMID: 36878044]
Shiming J, Nie T, Chengyu Z et al. The Distinctive Role of Membrane Fibrinogen-like Protein 2 in the Liver Stage of Rodent Malaria Infections. Parasite Immunol. 2022-10-27 [PMID: 36300695]
Xitang L, Qiang G, Wenhui W et al. FGL2-MCOLN3-Autophagy Axis-Triggered Neutrophil Extracellular Traps Exacerbate Liver Injury in Fulminant Viral Hepatitis. Cell Mol Gastroenterol Hepatol. 2022-01-01 [PMID: 35926777]
Xiaoying Y, Yaying S, Ze W et al. Proteinase-activated receptor-1 antagonist attenuates brain injury via regulation of FGL2 and TLR4 after intracerebral hemorrhage in mice. Neuroscience. 2022-02-17 [PMID: 35182700]
Yekaterina O, Yuliya P, Aikyn K et al. Fc Receptor is Involved in Nk Cell Functional Anergy Induced by Miapaca2 Tumor Cell Line. Immunol Invest. 2020-08-30 [PMID: 32865068]
Junjian H, Hongwu W, Xitang L et al. Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. Theranostics. 2020-08-01 [PMID: 32863955]
Shun W, Meng L, Feng X et al. Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization. Biomed Pharmacother. 2020-08-11 [PMID: 32795921]
Cildir G, Toubia J, Yip K et al. Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases. Immunity. 2019-10-22 [PMID: 31653482]
Zhu Y, Zhou J, Feng Y et al. Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2. Front Immunol. 2018-01-30 [PMID: 29441068]
Sun HJ, Chen J, Zhang H et al. Von Willebrand factor protects against acute CCl4-induced hepatotoxicity through phospho-p38 MAPK signaling pathway inhibition. munol Res 2017-09-03 [PMID: 28868583]
Wang M, Liu J, Xi D et al. Adenovirus-Mediated artificial miRNA against Human Fibrinogen Like Protein 2 Inhibits Hepatocellular Carcinoma Growth. J Gene Med 2016-05-10 [PMID: 27163335]
Long R, You Y, Li W et al. Sodium tanshinone IIA sulfonate ameliorates experimental coronary no-reflow phenomenon through down-regulation of FGL2. Life Sci. 2015-10-16 [PMID: 26482204]
Sun Y, Xi D, Ding W et al. Soluble FGL2, a novel effector molecule of activated hepatic stellate cells, regulates T-cell function in cirrhotic patients with hepatocellular carcinoma. Hepatol Int. 2014-09-25 [PMID: 25298849]
Li WZ, Wang J, Long R et al. Novel Antibody against a Glutamic Acid-Rich Human Fibrinogen-Like Protein 2-Derived Peptide near Ser91 Inhibits hfgl2 Prothrombinase Activity. PLoS One. 2014-04-11 [PMID: 24728278]
Xu GL, Chen J, Yang F et al. C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis via potentiating Fgl2/fibroleukin expression. Hepatology. 2014-05-28 [PMID: 24604562]
Ye X, Huai J, Chen R et al. Correlation of fibrinogen-like protein 2 with disease progression in patients with severe acute pancreatitis. Exp Ther Med. 2013-10-22 [PMID: 24348769]
Xi D, Wang M, Ye H et al. Combined Adenovirus-Mediated Artificial microRNAs Targeting mfgl2, mFas, and mTNFR1 Protect against Fulminant Hepatic Failure in Mice. PLoS One. 2013-11-26 [PMID: 24303082]
Dong X, Ye X, Chen X et al. Intestinal and peripheral fibrinogen-like protein 2 expression in inflammatory bowel disease. Dig Dis Sci. 2013-11-28 [PMID: 24287641]
Selzner N, Liu H, Boehnert MU et al. FGL2/Fibroleukin Mediates Hepatic Reperfusion Injury by Induction of Sinusoidal Endothelial Cell and Hepatocyte Apoptosis in Mice. J Hepatol. 2011-07-01 [PMID: 21756857]
Liu Y, Xu S, Xiao F et al. The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. Biochem Biophys Res Commun 396(2):555-61. 2010-05-28 [PMID: 20438701]
Shalev I, Wong K, Foerster K et al. The novel CD4+CD25+ regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis. Hepatology. 2009-02-15 [PMID: 19085958]
Shalev I, Liu H, Koscik C et al. Targeted Deletion of fgl2 Leads to Impaired Regulatory T Cell Activity Development of Autoimmune Glomerulonephritis1. J Immunol;180(1):249-60. 2008-01-01 [PMID: 18097026]
O'brien M, Morrison JJ, Smith TJ. Expression of Prothrombin Protease Activated Receptors in Human Myometrium During Pregnancy Labor. Biol Reprod;78(1):20-6. 2008-01-01 [PMID: 17901076]
Show All 25 Publications. Collapse Publications.

FGL2/Fibroleukin Antibody (6D9)

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Bioinformatics

Gene Symbol	FGL2
Entrez	10875(Human) 14190(Mouse) 84586(Rat)
OMIM	605351(Human)
Uniprot	NP_006673()