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FGF18 Antibody (91811) [Unconjugated]

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FGF‑18 was detected in immersion fixed paraffin-embedded sections of Human Uterine Cancer using Mouse Anti-Human FGF‑18 Monoclonal Antibody (Catalog # MAB6671) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasmic staining in tumor stroma. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
FGF‑18 was detected in immersion fixed paraffin-embedded sections of Human Uterine Cancer using Mouse Anti-Human FGF‑18 Monoclonal Antibody (Catalog # MAB6671) at 5 µg/mL for 1 hour at room ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
91811
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB6671-SP
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FGF18 Antibody (91811) [Unconjugated] Summary

Immunogen
E. coli-derived human FGF-18 protein
Glu28-Ala207
Accession # O76093
Specificity
Detects human FGF-18 by direct ELISA.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-15 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FGF18 Antibody (91811) [Unconjugated]

  • FGF18
  • FGF-18
  • FGF-18ZFGF5
  • fibroblast growth factor 18
  • zFGF5

Background

Fibroblast Growth Factor 18 (FGF-18) is a 20 kDa protein that plays an important role in skeletal development and bone homeostasis (1). Mature human FGF-18 shares 99% amino acid sequence identity with mouse and rat FGF-18 (2). It is expressed in embryonic somites and the neural fold (3), adult lung (2), cerebellar and hippocampal neurons (4), hair follicle root sheath cells (5), and osteogenic mesenchymal cells (6). FGF-18 binds to FGF R2c, FGF R3c (4, 7) as well as the Golgi protein GLG1 (8) and induces the proliferation of astrocytes and microglia, vascular endothelial cells, dermal fibroblasts, papilla cells, and keratinocytes (4, 5, 9). FGF-18 is required for normal skeletal development (6). It recruits osteoclasts and osteoblasts to the growth plate, promotes osteoclast formation and function, inhibits osteoblast differentiation, promotes skeletal vascularization, and induces chondrocyte hypertrophy and cartilage matrix formation (6, 7, 10, 11).
  1. Beenken, A. and M. Mohammadi (2009) Nat. Rev. Drug Discov. 8:235.
  2. Ohbayashi, N. et al. (1998) J. Biol. Chem. 273:18161.
  3. Ohuchi, H. et al. (2000) Mech. Dev. 95:55.
  4. Hoshikawa, M. et al. (2002) Brain Res. Mol. Brain Res. 105:60.
  5. Kawano, M. et al. (2005) J. Invest. Dermatol. 124:877.
  6. Ohbayashi, N. et al. (2002) Genes Dev. 16:870.
  7. Davidson, D. et al. (2005) J. Biol. Chem. 280:20509.
  8. Miyaoka, Y. et al. (2010) Development 137:159.
  9. Hu, M.C. et al. (1998) Mol. Cell. Biol. 18:6063.
  10. Liu, Z. et al. (2007) Dev. Biol. 302:80.
  11. Shimoaka, T. et al. (2002) J. Biol. Chem. 277:7493.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FGF18 Antibody
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