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FGF-23 Antibody (283511)

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Effects of conditional deletion of Fgfr1 in Hyp osteocytes on gross appearance and bone-related gene expressions in 6-week-old mice.(A) Gross appearance, tail length, and body weight. Compared with control mice, Fgfr1Dmp1-cKO-null mice had normal gross appearance and body weight. However, Hyp mice showed considerably shorter tail length and lower body weight, compound Hyp;Fgfr1Dmp1-cKO-null mice displayed intermediate tail length and body weight between control and Hyp mice. Data are mean ± S.D. from 5–6 individual mice. (B and C) Western blot analysis of total Fgf2 and Fgf23 protein levels in bone. A representative Fgf2, Fgf23, and beta -Actin gel were shown in upper, middle, and lower panels of B, respectively. The intensity of bands was quantified using Image J software (//rsb.info.nih.gov/ij/), and the data shown in C are mean ± S.D. from three independent experiments. Values sharing the same superscript in different groups are not significantly different at P<0.05. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0104154), licensed under a CC-BY license. Not internally tested by R&D Systems.
Effects of conditional deletion of Fgfr1 in Hyp osteocytes on gross appearance and bone-related gene expressions in 6-week-old mice.(A) Gross appearance, tail length, and body weight. Compared with control mice, ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clone
283511
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB2629-SP
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FGF-23 Antibody (283511) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse FGF-23
Tyr25-Val251 (Arg179Gln)
Accession # Q9EPC2
Specificity
Detects human and mouse FGF-23 in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) FGF acidic, rhFGF basic, rhFGF-3, -4, -5, -6, -7, -9, -10, -11, -12, -13, -16, -17, -18, -19, -20, -21, recombinant mouse (rm) FGF‑8b, rmFGF‑8c, or rmFGF-15.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
FGF23
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB2629 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FGF-23 Antibody (283511)

  • ADHR
  • FGF23
  • FGF-23
  • fibroblast growth factor 23
  • HPDR2
  • HYPF
  • phosphatonin
  • PHPTC
  • tumor-derived hypophosphatemia inducing factor
  • Tumor-derived hypophosphatemia-inducing factor

Background

FGF-23 is a secreted protein primarily expressed in the brain and thymus. Mutations in FGF-23 produced by osteomalacia tumors are linked to autosomal dominant hypophosphatemic rickets and several bone structure disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FGF-23 Antibody
(283511)
MAB2629
FGF-23 Antibody (283511)
Species: Hu, Mu
Applications: WB

Publications for FGF-23 Antibody (MAB2629)(6)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC, Western Blot.


Filter By Application
IHC
(1)
Western Blot
(4)
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Human
(2)
Mouse
(2)
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Showing Publications 1 - 6 of 6.
Publications using MAB2629 Applications Species
Kishimoto H, Nakano T, Torisu K et al. Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway Frontiers in cardiovascular medicine 2/21/2023 [PMID: 36895836]
N Quarto, S Shailendra, NP Meyer, S Menon, A Renda, MT Longaker Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23 Front Physiol, 2018-10-15;9(0):1426. 2018-10-15 [PMID: 30374308] (Western Blot, Mouse) Western Blot Mouse
ER Smith, SJ Tan, SG Holt, TD Hewitson FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts Sci Rep, 2017-06-13;7(1):3345. 2017-06-13 [PMID: 28611350] (IHC, Western Blot, Mouse) IHC, Western Blot Mouse
Zhousheng Xiao, Demian Riccardi, Hector A. Velazquez, Ai L. Chin, Charles R. Yates, Jesse D. Carrick et al. A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia Science Signaling 11/24/2016 [PMID: 27879395]
Xiao Z, Huang J, Cao L, Liang Y, Han X, Quarles L Osteocyte-specific deletion of Fgfr1 suppresses FGF23. PLoS ONE, 2014-08-04;9(8):e104154. 2014-08-04 [PMID: 25089825] (Western Blot, Human) Western Blot Human
Takaiwa M, Aya K, Miyai T Fibroblast growth factor 23 concentrations in healthy term infants during the early postpartum period. Bone, 2010-08-01;47(2):256-62. 2010-08-01 [PMID: 20641162] (Western Blot, Human) Western Blot Human

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Bioinformatics

Gene Symbol FGF23
Uniprot