SLC34A1 Antibody (10B1.3E9) - BSA Free

SLC34A1 / NaPi-IIa [Solute carrier family 34 (type II sodium/phosphate cotransporter), member 1] belongs to the type II sodium-phosphate cotransporter family and is a multi-pass membrane protein critically involved in the maintenance of renal inorganic phosphate (Pi) homeostasis and the plasma Pi levels. SLC34A1 acts as the most significant regulator of Pi homeostasis through its reabsorption via Na(+) cotransport in the brush border membrane of renal tissues. It is mainly expressed in the kidney wherein it accounts for 70-80% of the apical influx, however, its presence in some other tissues such as lungs, testes, fallopian tubes, and heart myocytes has also been documented (UniProt and Human Protein Atlas project databases). Signaling implicated in SLC34A1's regulation include the protein kinases A /C, ERK1/2, Klotho/KL, the PI3K/PKB/GSK3 kinase cascade, NHERF1/ SLC9A3R1, AMP-activated protein kinase AMPK, JAK2, and B-RAF. Moreover, SLC34A1 expression has been reported to be controlled by dietary Pi and hormones namely 1,25-dihydroxyvitamin D3, FGF23, Dopamine, Thyroid Hormone, Glucocorticoids, Estrogen /E2 and Triiodothyronine/T3. Besides renal Pi homeostasis, SLC34A1 has been suggested to be involved in several biological processes such as kidney development, bone remodeling, dentinogenesis, cholesterol metabolism, cellular response to metal ion/drug, parathyroid hormone stimulus, protein homooligomerization etc. SLC34A1 mutations have been shown to be associated with diseases such as Nephrolithiasis/osteoporosis, hypophosphatemic, 1 (NPHLOP1), Fanconi renotubular syndrome 2 (FRTS2) and idiopathic infantile hypercalcemia (IIH).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IF/IHC, IP, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP2-42216	Applications	Species
Friedman PA, Sneddon WB, Mamonova T et al. RGS14 regulates hormone-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein The Journal of biological chemistry 2022-03-17 [PMID: 35307350] (IP, Human)	IP	Human
Qian J, Zhong J, Liu S Et Al. alpha-Klotho, Plasma Asymmetrical Dimethylarginine, and Kidney Disease Progression Kidney Med 2021-12-23 [PMID: 34939007]
Bayer J, Vaghela R, Drechsler S et al. The bone is the major source of high circulating intact fibroblast growth factor-23 in acute murine polymicrobial sepsis induced by cecum ligation puncture PloS one 2021-05-14 [PMID: 33989306] (WB, Mouse)	WB	Mouse
Dhillon P, Park J, Hurtado Del Pozo C et al. The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation Cell metabolism 2020-12-01 [PMID: 33301705] (IF/IHC)	IF/IHC
Martins JS, Liu ES, Sneddon WB, et al 1,25-dihydroxyvitamin D maintains brush border membrane NaPi2a and attenuates phosphaturia in Hyp mice Endocrinology 2019-06-25 [PMID: 31237611]

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Mouse	08/17/2021	View Summary Application Western Blot Sample Tested Kidney tissue Species Mouse Lot 10B1.3E9

Array NBP2-42216

• SLC34A1 Antibodies
• SLC34A1 Lysate
• SLC34A1 Proteins