FCRL5/FcRH5/IRTA2 Antibody (1010552) [Alexa Fluor® 700]

Images

 
There are currently no images for FCRL5/FcRH5/IRTA2 Antibody (FAB20872N).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Applications Flow
Clone
1010552
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 700

Order Details

FCRL5/FcRH5/IRTA2 Antibody (1010552) [Alexa Fluor® 700] Summary

Immunogen
Mouse myeloma cell line, NS0-derived human FCRL5 protein
Gln16-Arg844
Accession # Q96RD9
Specificity
Detects human FCRL5 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Fc Receptor-Like 5 (FCRL5), also known as FcRH5, IRTA2, and CD307, is a 120 kDa protein with sequence homology to classical Fc receptors. The type 1 transmembrane FCRL proteins contain from three to nine immunoglobulin-like domains. They are differentially expressed within the B cell lineage and can either promote or inhibit B cell proliferation and activation (1, 2). According to R&D Systems testing, FCRL5 binds to purified human IgG with high affinity. Mature human FCRL5 consists of a 836 amino acid (aa) extracellular domain (ECD) with nine Ig-like domains, a 21 aa transmembrane segment, and a 105 aa cytoplasmic domain with one immunotyrosine activation motif (ITAM) and two immunotyrosine inhibitory motifs (ITIMs) (1, 3). Mouse FCRL5 contains only five Ig-like domains in its ECD. It shares 49% aa sequence identity with human FCRL5 within common regions. Alternate splicing of human FCRL5 generates isoforms that consist of approximately the first one, six, or eight Ig-like domains (3, 4). FCRL5 expression is restricted to mature B lineage cells in lymphoid tissues and blood (3, 5‑7). Its ligation inhibits signaling through the B cell antigen receptor (8). Epstein-Barr virus transformation of B cells induces the up‑regulation of surface FCRL5 by a direct effect of its EBNA2 protein on FCRL5 gene transcription (9). The FCRL5 gene maps to the 1q21 chromosomal locus, a common site of rearrangements in B cell malignancies, and the FCRL5 protein is preferentially expressed in cell lines with 1q21 abnormalities (3). FCRL5 is up‑regulated on tumor cells in some types of B cell malignancies (6, 10‑12). In addition, soluble FCRL5 is elevated in the serum of many B cell leukemia patients (11, 13).

  1. Davis, R.S. (2007) Annu. Rev. Immunol. 25:525.
  2. Maltais, L.J. et al. (2006) Nat. Immunol. 7:431.
  3. Hatzivassiliou, G. et al. (2001) Immunity 14:277.
  4. SwissProt # Q96RD9.
  5. Miller, I. et al. (2002) Blood 99:2662.
  6. Polson, A.G. et al. (2006) Int. Immunol. 18:1363.
  7. Vidal-Laliena, M. et al. (2005) Cell. Immunol. 236:6.
  8. Haga, C.L. et al. (2007) Proc. Natl. Acad. Sci. 104:9770.
  9. Mohan, J. et al. (2006) Blood 107:4433.
  10. Ise, T. et al. (2005) Clin. Cancer Res. 11:87.
  11. Ise, T. et al. (2007) Leukemia 21:169.
  12. Kazemi, T. et al. (2009) Cancer Immunol. Immunother. 58:989.
  13. Ise, T. et al. (2006) Clin. Chem. Lab. Med. 44:594.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

MAB3126
Species: Hu
Applications: CyTOF-ready, Flow
MAB7905
Species: Mu
Applications: CyTOF-ready, Flow, WB
MAB2048
Species: Hu
Applications: CyTOF-ready, Flow, WB
AF7286
Species: Mu
Applications: CyTOF-ready, Flow
NB100-56516
Species: Hu, Mu
Applications: IHC, IHC-P, WB
AF3117
Species: Hu, Mu, Rt
Applications: CyTOF-ready, Flow, ICC, Simple Western, WB
AF165
Species: Hu
Applications: CyTOF-ready, Flow, WB
AF5129
Species: Hu
Applications: WB
AF1162
Species: Hu
Applications: CyTOF-ready, Flow, IHC, Neut, WB
MAB10541
Species: Hu
Applications: CyTOF-ready, Flow, ICC, Neut
462-TEC
Species: Mu
Applications: BA
MAB4705
Species: Hu
Applications: CyTOF-ready, ICFlow, WB
AF193
Species: Hu
Applications: Block, CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta), ELISA(Sta), ELISA, Flow, WB
NBP1-33427
Species: Hu
Applications: ChIP, ICC/IF, WB
NB100-524
Species: Hu, Mu
Applications: Flow-IC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
FAB20872N
Species: Hu
Applications: Flow

Publications for FCRL5/FcRH5/IRTA2 Antibody (FAB20872N) (0)

There are no publications for FCRL5/FcRH5/IRTA2 Antibody (FAB20872N).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for FCRL5/FcRH5/IRTA2 Antibody (FAB20872N) (0)

There are no reviews for FCRL5/FcRH5/IRTA2 Antibody (FAB20872N). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for FCRL5/FcRH5/IRTA2 Antibody (FAB20872N) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional FCRL5/FcRH5/IRTA2 Products

Blogs on FCRL5/FcRH5/IRTA2

There are no specific blogs for FCRL5/FcRH5/IRTA2, but you can read our latest blog posts.
Read our latest blog and use the new citation tool on bio-techne.com

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our FCRL5/FcRH5/IRTA2 Antibody (1010552) [Alexa Fluor® 700] and receive a gift card or discount.