FAT4 Antibody - BSA Free

FAT4 (FAT tumor suppressor homolog 4, also know as Fat-J, mFat4, and CDHF14) is a member of the Cadherin superfamily. Members of the Cadherin superfamily positively regulate planar cell polarity (PCP) in drosophila wings and play an important role in cell to cell adhesion interactions. FAT4 and other Cadherin family members have been used in systems medicine; especially in the fields of oncology and neurology (PMID: 16865240). FAT4 is widely expressed in most tissues, especially fetal and infant brain. It is also expressed in brain tumors and colorectal cancer. Furthermore, human breast tumor cell lines and primary tumors show a loss of FAT4 expression. Promoter methylation of a FAT4 allele can inactivate the expression of the FAT4 gene in deleted regions of the Hippo signaling pathway, the pathway that controls organ size (PMID: 19048595).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: FLOW, IHC-P, WB.

Showing Publications 1 - 8 of 8.

Publications using NBP1-78381	Applications	Species
Hoelting TLB, Cidre-Aranaz F, Matzek D, Popper B Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma bioRxiv 2022-01-01 [PMID: 36229873] (FLOW, Mouse)	FLOW	Mouse
Jung HY, Cho H, Oh MH et al. Loss of FAT Atypical Cadherin 4 Expression Is Associated with High Pathologic T Stage in Radically Resected Gastric Cancer J Gastric Cancer 2015-03-01 [PMID: 25861521] (IHC-P, Human)	IHC-P	Human
Wang X Loss of FAT4 induces aneuploidy in urothelial cells and promotes the invasive and migratory capacities of bladder cancer cell lines Thesis 2023-01-01
Jiang X, Liu Z, Xia Y et al. Low FAT4 expression is associated with a poor prognosis in gastric cancer patients. Oncotarget 2018-01-12 [PMID: 29435168] (IHC-P, Mouse)	IHC-P	Mouse
Bliss SA, Paul S, Pobiarzyn PW et al. Evaluation of a developmental hierarchy for breast cancer cells to assess risk-based patient selection for targeted treatment Sci Rep 2018-01-10 [PMID: 29321622] (WB, Human)	WB	Human
Pujol F, Hodgson T, Martinez-Corral I et al. Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis Arterioscler. Thromb. Vasc. Biol. 2017-07-13 [PMID: 28705793]
Jie-Yi Shi, Qingfeng Xing, Meng Duan, Zhi-Chao Wang, Liu-Xiao Yang, Ying-Jun Zhao, Xiao-Ying Wang, Yun Liu, Minghua Deng, Zhen-Bin Ding, Ai-Wu Ke, Jian Zhou, Jia Fan, Ya Cao, Jiping Wang, Ruibin Xi, Qiang Gao Inferring the progression of multifocal liver cancer from spatial and temporal genomic heterogeneity Oncotarget 2016-01-19 [PMID: 26672766]
Furukawa T, Sakamoto H, Takeuchi S et al. Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas Sci Rep 2015-03-06 [PMID: 25743105] (IHC-P, Human) Details: FAT4 antibody used for IHC-P analysis of paraffin processed tissue sections of human acinar cell carcinoma. The IHC-P assay was performed using streptavidin and biotin based detection kit namely - Histofine SAB-PO kit.	IHC-P	Human

Array NBP1-78381

• FAT4 Antibodies
• FAT4 Proteins