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ErbB2/Her2 Antibody (Hu5) [DyLight 755]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, B/N, CyTOF-ready
Clone
Hu5
Clonality
Monoclonal
Host
Human
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB9589U-100UG
Alexa Fluor 405
FAB9589V-100UG
Alexa Fluor 488
FAB9589G-100UG
Alexa Fluor 532
FAB9589X
Alexa Fluor 594
FAB9589T-100UG
Alexa Fluor 647
FAB9589R-100UG
Alexa Fluor 700
FAB9589N-100UG
Alexa Fluor 750
FAB9589S-100UG
Allophycocyanin
FAB9589A
Allophycocyanin/Cy7
FAB9589APCCY7
Biotin
FAB9589B-100
CoraFluor 1
FAB9589CL1
DyLight 350
FAB9589D
DyLight 405
FAB9589E
DyLight 488
FAB9589K
DyLight 550
FAB9589L
DyLight 594
FAB9589M
DyLight 650
FAB9589W
DyLight 680
FAB9589Y
FITC
FAB9589F
HRP
FAB9589H
Janelia Fluor 525
FAB9589JF525
Janelia Fluor 549
FAB9589I
Janelia Fluor 585
FAB9589JF585
Janelia Fluor 635
FAB9589JF635
Janelia Fluor 646
FAB9589J
Janelia Fluor 669
FAB9589JF669
PE/Atto594
FAB9589PEATT594
PE/Cy5.5
FAB9589PECY55
PE/Cy7
FAB9589PECY7
PerCP
FAB9589C
Phycoerythrin
FAB9589P-100
Unconjugated
MAB9589-100
mFluor Violet 450 SE
FAB9589MFV450
mFluor Violet 500 SE
FAB9589MFV500
mFluor Violet 610 SE
FAB9589MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB9589-100
Carrier Free
FAB9589B-100
Carrier Free
MAB9589-100
Carrier Free
MAB9589-SP
Carrier Free
FAB9589V-100UG
Carrier Free
FAB9589T-100UG
Carrier Free
FAB9589R-100UG
Carrier Free
FAB9589S-100UG
Carrier Free
FAB9589N-100UG
Carrier Free
FAB9589U-100UG
Carrier Free
FAB9589G-100UG
Carrier Free
FAB9589P-100
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ErbB2/Her2 Antibody (Hu5) [DyLight 755] Summary

Immunogen
Human ErbB2/Her2
Specificity
Detects human ErbB2/Her2 in direct ELISAs. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Trastuzumab. This product is for research use only.
Isotype
IgG1
Clonality
Monoclonal
Host
Human
Purity
Protein A or G purified from cell culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Inhibition of Cell Growth
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from cell culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for ErbB2/Her2 Antibody (Hu5) [DyLight 755]

  • CD340 antigen
  • CD340
  • c-erb B2/neu protein
  • EC 2.7.10
  • EGFR2
  • ErbB2
  • HER2
  • HER-2
  • HER2EC 2.7.10.1
  • herstatin
  • Metastatic lymph node gene 19 protein
  • MLN 19
  • MLN19
  • Neu Oncogene
  • NEUHER-2/neu
  • neuroblastoma/glioblastoma derived oncogene homolog
  • NGL
  • NGLTKR1
  • p185erbB2
  • Proto-oncogene c-ErbB-2
  • Proto-oncogene Neu
  • receptor tyrosine-protein kinase erbB-2
  • TKR1
  • Tyrosine kinase-type cell surface receptor HER2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)

Background

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for ErbB2/Her2 Antibody (FAB9589Z). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in getting antibodies for HER that would work in flow cytometry. Could you recommend some choices?
    • A list of our ErbB2 antibodies validated for use in flow cytometry can be found here /productsearch/HER2#fq=common_name%3A%22ErbB2%2FHER2%22&fq=category%3A%22Primary%20Antibodies%22&fq=applications%3A%22Flow%20Cytometry%22

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