EPCR Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. Protein C is a vitamin K-dependent serine protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (protease-activated receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes.  The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 9 applications: Binding Assay, Dot Blot, ELISA Development, Flow Cytometry, ICC, IHC, IHC-P, Immunocytochemistry, Western Blot.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using AF2245	Applications	Species
L Di Pietro, F Giacalone, E Ragozzino, V Saccone, F Tiberio, M De Bardi, M Picozza, G Borsellino, W Lattanzi, E Guadagni, S Bortolani, G Tasca, E Ricci, O Parolini Non-myogenic mesenchymal cells contribute to muscle degeneration in facioscapulohumeral muscular dystrophy patients Cell Death & Disease, 2022-09-16;13(9):793. 2022-09-16 [PMID: 36114172] (IHC, Human)	IHC	Human
ML Bochenek, R Gogiraju, S Gro beta mann, J Krug, J Orth, S Reyda, GS Georgiadis, H Spronk, S Konstantin, T Münzel, JH Griffin, PS Wild, C Espinola-K, W Ruf, K Schäfer EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia JCI Insight, 2022-07-22;0(0):. 2022-07-22 [PMID: 35700057] (IHC, Western Blot, Human, Mouse)	IHC, Western Blot	Human, Mouse
Sreemanti Basu, Hai Po Helena Liang, Irene Hernandez, Mark Zogg, British Fields, Jennifer May et al. Role of thrombomodulin expression on hematopoietic stem cells Journal of Thrombosis and Haemostasis 1/1/2020 [PMID: 31628891]
M Avril, M Benjamin, MM Dols, JD Smith Interplay of Plasmodium falciparum and thrombin in brain endothelial barrier disruption Sci Rep, 2019-09-11;9(1):13142. 2019-09-11 [PMID: 31511575] (Flow Cytometry, Human)	Flow Cytometry	Human
G Ecklu-Mens, RW Olsen, A Bengtsson, MF Ofori, L Hviid, ATR Jensen, Y Adams Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes PLoS ONE, 2018-10-09;13(10):e0204177. 2018-10-09 [PMID: 30300360] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
A. M. Fager, K. R. Machlus, M. Ezban, M. Hoffman Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity Journal of Thrombosis and Haemostasis 9/1/2018 [PMID: 29879294]
H Lécuyer, Z Virion, JP Barnier, S Matczak, S Bourdoulou, E Bianchini, F Saller, D Borgel, X Nassif, M Coureuil An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans PLoS Pathog., 2018-04-09;14(4):e1006981. 2018-04-09 [PMID: 29630665] (Immunocytochemistry, Human)	Immunocytochemistry	Human
Y Azasi, G Lindergard, A Ghumra, J Mu, LH Miller, JA Rowe Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):. 2018-01-16 [PMID: 29339517] (Binding Assay, Human)	Binding Assay	Human
Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum-Infected Erythrocytes to Endothelial Cells MBio, 2016-07-12;7(4):. 2016-07-12 [PMID: 27406562] (Flow Cytometry, Human)	Flow Cytometry	Human
DALEL AZZAZENE, HAMDA AL Al Thawadi, HALEMA AL Al Farsi, SAMAHER BESBES, CAROLINE GEYL, SHAHSOLTAN MIRSHAHI et al. Plasma endothelial protein C receptor influences innate immune response in ovarian cancer by decreasing the population of natural killer and TH17 helper cells International Journal of Oncology 10/1/2013 [PMID: 23877403]
Elodie Ducros, Shah Soltan Mirshahi, Anne‐Marie Faussat, Pezhman Mirshahi, Sophie Dimicoli, Ruoping Tang et al. Soluble endothelial protein C receptor (sEPCR) is likely a biomarker of cancer‐associated hypercoagulability in human hematologic malignancies Cancer Medicine 10/1/2012 [PMID: 23342274]
Karhemo PR, Ravela S, Laakso M et al. An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis. J Proteomics. 7/17/2012 [PMID: 22813880]
ELODIE DUCROS, SHAHSOLTAN MIRSHAHI, DALEL AZZAZENE, SOPHIE CAMILLERI-BROËT, ELIANE MERY, HALEMA AL Al Farsi et al. Endothelial protein C receptor expressed by ovarian cancer cells as a possible biomarker of cancer onset International Journal of Oncology 8/1/2012 [PMID: 22614534]
Campbell JE, Brummel-Ziedins KE, Butenas S Cellular regulation of blood coagulation: a model for venous stasis. Blood, 2010-09-23;116(26):6082-91. 2010-09-23 [PMID: 20864579] (ICC, Human)	ICC	Human
Gunawardana CG, Kuk C, Smith CR Comprehensive analysis of conditioned media from ovarian cancer cell lines identifies novel candidate markers of epithelial ovarian cancer. J. Proteome Res., 2009-10-01;8(10):4705-13. 2009-10-01 [PMID: 19663500] (ELISA Development, Human)	ELISA Development	Human
Ducros E, Berthaut A, Mirshahi SS, Faussat AM, Soria J, Agarwal MK, Mirshahi M Aldosterone modifies hemostasis via upregulation of the protein-C receptor in human vascular endothelium. Biochem. Biophys. Res. Commun., 2008-06-13;373(2):192-6. 2008-06-13 [PMID: 18555797] (Dot Blot, Flow Cytometry, ICC, Human)	Dot Blot, Flow Cytometry, ICC	Human
Xue M, Campbell D, Jackson CJ Protein C is an autocrine growth factor for human skin keratinocytes. J. Biol. Chem., 2007-02-09;282(18):13610-6. 2007-02-09 [PMID: 17293597] (IHC-P, Human)	IHC-P	Human
Show All 17 Publications. Collapse Publications.

Array AF2245

• EPCR Antibodies
• EPCR Lysate
• EPCR Proteins
• EPCR Proteins and Enzymes
• EPCR ELISA