PAR1/Thrombin Receptor Antibody (N2-11)

Thrombin, the main effector protease of coagulation cascade, is a most potent platelet activator and its actions on platelets are mediated by Thrombin Receptors (also called platelet protease-activated receptors, PARs), which are GPCR members of 7-transmembrane domain receptor superfamily. PARs subtypes includes: PAR-1, PAR-2, PAR-3, and PAR-4, and in addition to platelets, they are also located in smooth muscle cells, endothelial cells, and fibroblasts. PAR1 or thrombin receptor (F2R) is a prototypical GPCR activated by thrombin's lowest concentration compared to other PARs and after cleavage of the extreme N-terminal peptide, the exposed tethered ligand of PAR1 activates itself for participation in diverse physiological processes including coagulation, inflammation, and vascular homeostasis. PAR1 knockout in mouse leads to death of pups in midgestation due to impaired vascular development as well as severe bleeding, whereas endothelial cell-specific reintroduction of PAR1 can rescue the phenotype. PAR1 has emerged as a target for anti-platelet therapies which are useful for ACS (acute coronary syndromes), stable coronary disease, ischemic atherothrombotic stroke, and peripheral arterial disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: ICC/IF, IF, IF/IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 10 of 10.

Publications using NBP1-71770	Applications	Species
YS Hwang, HJ Cho, ES Park, J Lim, HR Yoon, JT Kim, SR Yoon, H Jung, YK Choe, YH Kim, CH Lee, YT Kwon, BY Kim, HG Lee KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages Cells, 2022-12-16;11(24):. 2022-12-16 [PMID: 36552865]
Hayashi Y, Shimizu I, Yoshida Y et al. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity iScience 2022-07-15 [PMID: 35754738] (IHC-P, Mouse)	IHC-P	Mouse
Goldberg Z, Sher I, Qassim L et al. Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers International journal of molecular sciences 2022-01-17 [PMID: 35055169] (WB, IF, Mouse)	WB, IF	Mouse
Chen R, Cao X, et al. Dabigatran Suppresses PAR-1/SphK/S1P Activation of Astrocytes in Experimental Autoimmune Encephalomyelitis Model. Front Mol Neurosci 2020-07-23 [PMID: 32694981]
Nishimura F, Mogami H, Moriuchi K et al. Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone PLoS ONE 2020-05-04 [PMID: 32365105] (IHC-P, Human)	IHC-P	Human
Kim MJ, Park KH, Lee JY et al. Weisheng-Tang Ameliorates Acute Ischemic Brain Damage in Mice by Maintaining Blood-Brain Barrier Integrity Oxid Med Cell Longev 2019-12-03 [PMID: 31885791] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Komori M, Ago T, Wakisaka Y, et al. Early initiation of a factor Xa inhibitor can attenuate tissue repair and neurorestoration after middle cerebral artery occlusion Brain Res. 2019-05-16 [PMID: 31103522] (IF/IHC, Mouse)	IF/IHC	Mouse
Choi CI, Yoon H, Drucker KL et al. The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation Sci Rep 2018-06-19 [PMID: 29921916] (IF/IHC, ICC/IF, Mouse)	IF/IHC, ICC/IF	Mouse
Kim HN, Kim YR, Ahn SM et al. Protease activated receptor-1 antagonist ameliorates the clinical symptoms of experimental autoimmune encephalomyelitis via inhibiting breakdown of blood brain barrier. J. Neurochem. 2015-08-18 [PMID: 26285165] (WB, Mouse)	WB	Mouse
Gonda K, Watanabe TM, Ohuchi N, Higuchi H. In vivo nano-imaging of membrane dynamics in metastatic tumor cells using quantum dots. J Biol Chem;285(4):2750-7. 2010-01-22 [PMID: 19917603] (ICC/IF, Mouse)	ICC/IF	Mouse

Array NBP1-71770

• PAR1/Thrombin Receptor Antibodies
• PAR1/Thrombin Receptor ELISA Kit
• PAR1/Thrombin Receptor Lysate
• PAR1/Thrombin Receptor Proteins