EMAP-II/AIMP1 Antibody

AIMP1, short for Aminoacyl tRNAse synthetase complex-interacting multifunctional protein 1, is also called p43 (~43 kDa molecular weight). Along with AIMP2 and AIMP3, AIMP1 is one of the three auxiliary proteins which bind to the aminoacyl tRNase synthetase complex. The AIMPs together with the Aminoacyl tRNAse synthetase, ARS, complex perform a critical role in protein synthesis but also in biological processes such as apoptosis, angiogenesis and inflammation (1, 2). AIMP1 is characterized as a pleiotropic cytokine that enhances TLR1, TLR2, TLR3 and TLR7 expression in BM-DCs. AIMP1 also enhances DC production of IL-6 and IL-12 and increases NF-kB activity (3, 4). AIMP1 has demonstrated to immune-stimulating activities as well as anti-tumor activities in mouse xenograft models (5). Expression AIMP1 and AIMP2 and 3 proteins are diminished in certain cancers (6). Overall, AIMPs may act as tumor suppressors and perhaps may be considered as a focused target for cancer treatment candidates.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-27206	Applications	Species
Phulphagar K, Kuhn LI, Ebner S et al. Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis Cell reports 2021-03-09 [PMID: 33691121] (WB, Human, Mouse)	WB	Human, Mouse
Dawson HD, Sang Y, Lunney JK Porcine cytokines, chemokines and growth factors: 2019 update Res. Vet. Sci. 2020-08-01 [PMID: 32442727] (WB, Porcine)	WB	Porcine

Array NBP2-27206

• EMAP-II/AIMP1 Antibodies
• EMAP-II/AIMP1 ELISA Kit
• EMAP-II/AIMP1 Proteins
• EMAP-II/AIMP1 Proteins and Enzyme