eIF4G1 Antibody

eIF4G1 (eukaryotic translation Initiation Factor 4 Gamma 1) is a component of the protein complex eIF-4 which is involved in the recognition of the mRNA cap ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of mRNA to the ribosome. eIF4G plays a critical role in protein expression and is at the center of a complex regulatory network. Together with the cap-binding protein eIF4E, it recruits the small ribosomal subunit to the 5'-end of mRNA and promotes the assembly of a functional translation initiation complex which scans along the mRNA to the translation start codon. Human eIF4G contains three consecutive HEAT domains, as well as long unstructured regions involved in multiple protein-protein interactions. The interactions of eIF4G1 with other factors are largely unknown.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Porcine.

We have publications tested in 1 application: WB.

Showing Publications 1 - 10 of 26. Show All 26 Publications. Collapse Publications.

Publications using NB100-268	Applications	Species
Mendez-Solis O, Bendjennat M, Naipauer J et al. Kaposi's sarcoma herpesvirus activates the hypoxia response to usurp HIF2alpha-dependent translation initiation for replication and oncogenesis Cell reports 2021-12-28 [PMID: 34965440] (WB)	WB
Hernandez-Garcia AD, Columbus DA, Manjarin R et al. Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia Am. J. Physiol. Endocrinol. Metab. 2016-09-13 [PMID: 27624100] (WB, Porcine)	WB	Porcine
Galicia-Vazquez G, Cencic R, Robert F et al. A cellular response linking eIF4AI activity to eIF4AII transcription. RNA 2012-07-01 [PMID: 22589333]
El-Kadi SW, Suryawan A, Gazzaneo MC et al. Anabolic Signaling and Protein Deposition Are Enhanced by Intermittent as Compared with Continuous Feeding in Skeletal Muscle of Neonates. American Journal of Physiology, Endocrinology and Metabolism. 2012-01-01 [PMID: 22215651]
Gazzaneo MC, Suryawan A, Orellana RA et al. Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs J Nutr 2011-12-01 [PMID: 22013195] (WB, Porcine)	WB	Porcine
Cencic R, Hall DR, Robert F et al. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A 2011-01-01 [PMID: 21191102]
Sharma A, Hoeffer CA, Takayasu Y et al. Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci 2010-01-01 [PMID: 20071534]
Chale-Rush A, Morris EP, Kendall TL et al. Effects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged rats. J Gerontol A Biol Sci Med Sci 2009 Dec [PMID: 19808838]
Wilson FA, Suryawan A, Orellana RA et al. Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation. J Nutr 2009-10-01 [PMID: 19692527]
Spurgeon ME, Ornelles DA. The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection. J Virol 2009-10-01 [PMID: 19605483]
Suryawan A, Jeyapalan AS, Orellana RA et al. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. Am J Physiol Endocrinol Metab 2008-10-01 [PMID: 18682538]
Wilson FA, Suryawan A, Orellana RA et al. Fed levels of amino acids are required for the somatotropin-induced increase in muscle protein synthesis. Am J Physiol Endocrinol Metab 2008-10-01 [PMID: 18682537]
Lin CJ, Cencic R, Mills JR et al. c-Myc and eIF4F are components of a feedforward loop that links transcription and translation. Cancer Res 2008-07-01 [PMID: 18593934]
Wilson FA, Orellana RA, Suryawan A et al. Stimulation of muscle protein synthesis by somatotropin in pigs is independent of the somatotropin-induced increase in circulating insulin. Am J Physiol Endocrinol Metab 2008-07-01 [PMID: 18460595]
Escobar, J, J W Frank et al. Amino acid Availability Age Affect the Leucine Stimulation of Protein Synthesis eIF4F Formation in Muscle: 00302. 2007-01-01 [PMID: 17878223]
Gelinas JN, Banko JL, Hou L et al. ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation. J Biol Chem 2007-09-01 [PMID: 17635924]
Otulakowski G, Duan W, Gandhi S et al. Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia. Am J Respir Cell Mol Biol 2007-10-01 [PMID: 17556672]
Vary TC, Anthony JC, Jefferson LS et al. Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle. Am J Physiol Endocrinol Metab 2007-07-01 [PMID: 17389711]
Bordeleau ME, Cencic R, Lindqvist L et al. RNA-mediated sequestration of the RNA helicase eIF4A by Pateamine A inhibits translation initiation. Chem Biol 2006-12-01 [PMID: 17185224]
Yang R, Weber DJ, Carrier F et al. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18. Nucleic Acids Res 2006-03-01 [PMID: 16513844]
Banko JL, Hou L, Poulin F et al. Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression. J Neurosci 2006-02-01 [PMID: 16495443]
Funai K, Parkington JD, Carambula S et al. Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle. Am J Physiol Regul Integr Comp Physiol 2006-04-01 [PMID: 16306159]
Vary TC, Lynch CJ. Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4E availability and eIF4G phosphorylation. Am J Physiol Endocrinol Metab 2006-04-01 [PMID: 16263769]
Harber MP, Schenk S, Barkan AL et al. Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis. J Clin Endocrinol Metab 2005-09-01 [PMID: 15972575]
Vary TC, Deiter G, Goodman SA et al. Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling. Am J Physiol Heart Circ Physiol 2005-01-01 [PMID: 15388509]
Lang CH, Frost RA, Svanberg E et al. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am J Physiol Endocrinol Metab 2004-06-01 [PMID: 14749210]
Show All 26 Publications. Collapse Publications.

Array NB100-268

• eIF4G1 Antibodies
• eIF4G1 Lysate
• eIF4G1 Proteins