eIF2 alpha/EIF2S1 Antibody (3H12-C11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

EIF2S1, also known as eIF2a, is the alpha subunit of the translation initiation factor eIF2 complex which catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. The phosphorylation state of eIF2S1 controls the rate of tRNA translation. When eIF2a is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2S1 is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation. Recombinant human EIF2S1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using H00001965-M01	Applications	Species
Weinlich S, Huttelmaier S, Schierhorn A et al. IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR. RNA;15(8):1528-42. 2009-08-01 [PMID: 19541769]

Array H00001965-M01

• eIF2 alpha/EIF2S1 Antibodies
• eIF2 alpha/EIF2S1 Lysate
• eIF2 alpha/EIF2S1 Proteins