EGFR [p Tyr1197] Antibody (869286) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

EGF receptor, also known as ErbB1, is an approximately 160 kDa transmembrane receptor tyrosine kinase that binds multiple EGF family proteins. Ligand binding induces EGFR homodimerization or heterodimerization with ErbB2, 3,or 4 as well as activation of its kinase domain and phosphorylation within the cytoplasmic domain. Phosphorylation of Tyr869 by Src is important for full activation of the receptor. Phosphorylation of Tyr1197 by MAP kinases contributes to EGFR interaction with PIK3C2B. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. Three additional alternative splice forms lack the transmembrane and cytoplasmic domains. Within the ECD, human EGFR shares 88% aa sequence identity with mouse and rat EGFR.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB8274

• EGFR Antibodies
• EGFR Antibody Pair
• EGFR Lysate
• EGFR Proteins
• EGFR Proteins and Enzymes
• EGFR ELISAs