DGAT2 Antibody - BSA Free

Diacylglycerol acyltransferase enzyme 2 is localized within the endoplasmic reticulum, mitochondria and lipid droplets. It catalyzes triacylglycerol synthesis, which creates the major form of stored energy in cells. In mice, when DGAT2 is overexpressed in the liver, hepatocytes have abnormally high levels of lipid retention, elevated triglyceride, diacylglycerol and ceramide, while maintaining a normal insulin response. This indicates that insulin resistance and elevated hepatic lipid retention are associated. DGAT2 is associated with increases in PKC activation, which is implicated in the formation of nonalcoholic fatty liver disease. DGAT2 is critical for lipid droplet formation in adipocytes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 9 of 9.

Publications using NBP1-71701	Applications	Species
Moliterni C, Vari F, Schifano E et Al. Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPAR? activation in liver cells J Lipid Res 2024-11-04 [PMID: 39505261]
Eui-Jin Lee, Yeon-Pyo Hong, Yun-Jung Yang Short-term exposure to di(2-ethylhexyl)phthalate may disrupt hepatic lipid metabolism through modulating the oxidative stress in male adolescent rats Environmental Analysis, Health and Toxicology 2024-03-01 [PMID: 38631399]
S T, S L, F G et al. An aqueous olive leaf extract (OLE) ameliorates parameters of oxidative stress associated with lipid accumulation and induces lipophagy in human hepatic cells Food & function 2023-06-19 [PMID: 37294271] (WB, Human) Details: 1:1000 dilution	WB	Human
Yamasaki S, Kimura G, Koizumi K et al. Maternal green tea extract intake during lactation attenuates hepatic lipid accumulation in adult male rats exposed to a continuous high-fat diet from the foetal period Food & Nutrition Research 2020-10-05 [PMID: 34908919]
Kim JH, Nagappan A, Jung DY Et al. Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2 International journal of molecular sciences 2021-10-14 [PMID: 34681759] (WB, Mouse)	WB	Mouse
Romano A, Friuli M, Del Coco L, et al. Chronic Oleoylethanolamide Treatment Decreases Hepatic Triacylglycerol Level in Rat Liver by a PPAR gamma /SREBP-Mediated Suppression of Fatty Acid and Triacylglycerol Synthesis Nutrients 2021-01-27 [PMID: 33513874]
Zhang J, Novakovic N, Hua Y et al. Role of lipocalin-2 in extracellular peroxiredoxin 2-induced brain swelling, inflammation and neuronal death Experimental Neurology [PMID: 33129840] (WB, Rat)	WB	Rat
Paland N, Gamliel-Lazarovich A, Coleman R, Fuhrman B. Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2. Atherosclerosis. 2014-09-09 [PMID: 25244504] (WB, Human)	WB	Human
Yang A, Gyulay G, Mitchell M et al. Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice J Lipid Res 2012-12-01 [PMID: 22984145]

Array NBP1-71701

• DGAT2 Antibodies
• DGAT2 ELISA Kits
• DGAT2 Proteins