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Claudin-18.2 Antibody (3B2B5)

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Immunohistochemistry: Claudin-18.2 Antibody (3B2B5) [NBP3-33351] - Immunohistochemistry analysis of paraffin-embedded Human stomach using Claudin-18.2 Rabbit mAb at dilution of 1:400 (40x lens). Microwave antigen retrieval performed with 0.01M Tris/EDTA Buffer (pH 9.0) prior to IHC staining.
Immunohistochemistry: Claudin-18.2 Antibody (3B2B5) [NBP3-33351] - Immunohistochemistry analysis of paraffin-embedded Human stomach using Claudin-18.2 Rabbit mAb at dilution of 1:400 (40x lens). Microwave antigen ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, IHC
Clone
3B2B5
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

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Claudin-18.2 Antibody (3B2B5) Summary

Immunogen
Recombinant protein of human Claudin-18.2.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
CLDN18
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • ELISA Recommended starting concentration is 1 ug/mL
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100 - 1:500
Theoretical MW
28 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 50% glycerol, 0.05% BSA
Preservative
0.05% Proclin 300
Purity
Affinity purified

Alternate Names for Claudin-18.2 Antibody (3B2B5)

  • claudin-18
  • SFTA5
  • SFTPJ
  • surfactant associated 5
  • surfactant associated protein J
  • surfactant, pulmonary associated protein J

Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Claudin-18.2
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Claudin-18.2 Antibody (3B2B5)
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Array NBP3-33351

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Bioinformatics

Gene Symbol CLDN18