CHIP/STUB1 Antibody

This antibody can be used as the primary antibody in a PLA assay with the following as complementing antibodies:NBP1-19098, NB200-171, NB200-347

STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down's syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using NB100-77315	Applications	Species
Tsvetkov P, Adamovich Y, Elliott E et al. E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients. J Biol Chem 2011-03-01 [PMID: 21220432]
Luo, W, Zhong, J, Chang, R, Hu, H, Pandey, A, Semenza, GL. HSP70 and CHIP selectively mediate Ubiquitination and degradation of hypoxia-inducible factor (HIF)-1a but not HIF-2a J. J. Biol. Chem. jbc.M109.068577, doi:10.1074/jbc.M109.068577. 2009-11-23 [PMID: 19940151]

Array NB100-77315

• CHIP/STUB1 Antibodies
• CHIP/STUB1 Lysate
• CHIP/STUB1 Proteins