CHIP/STUB1 Products

Description

STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down's syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53. Alternate names for STUB1/CHIP include carboxy terminus of Hsp70-interacting protein, STIP1 homology and U-box containing protein 1, CLL-associated antigen KW-8 antigen, serologically defined colon cancer antigen 7, heat shock protein A binding protein 2, NY-CO-7, HSPABP2, and SDCCAG7.

Bioinformatics

Entrez	10273 Human 56424 Mouse
Uniprot	NP_005852 Human NP_005852. Human NP_005852.2 Human Q969U2 Human Q9UNE7 Human
Product By Gene ID	10273
Alternate Names	Antigen NY-CO-7 Carboxy terminus of Hsp70-interacting protein CHIPSTIP1 homology and U box-containing protein 1 CLL-associated antigen KW-8 E3 ubiquitin-protein ligase CHIP EC 6.3.2.- heat shock protein A binding protein 2 (c-terminal) HSPABP2 NY-CO-7 SDCCAG7 serologically defined colon cancer antigen 7 STIP1 homology and U-box containing protein 1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase UBOX1

Research Areas for CHIP/STUB1

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Neuroscience