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Caspase 5 Antibody [mFluor Violet 450 SE]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
mFluor Violet 450 SE

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Caspase 5 Antibody [mFluor Violet 450 SE] Summary

Immunogen
Produced in rabbits immunized with E. coli-derived Human Caspase 5 fragment.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CASP5
Purity
Antigen and protein A Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Antigen and protein A Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Caspase 5 Antibody [mFluor Violet 450 SE]

  • CASP5
  • CASP-5
  • caspase 5, apoptosis-related cysteine peptidase
  • caspase 5, apoptosis-related cysteine protease
  • Caspase5
  • Caspase-5
  • EC 3.4.22
  • EC 3.4.22.58
  • ICE(rel)III
  • ICE(rel)-III
  • ICEREL-III
  • ICH3
  • ICH-3
  • MGC141966
  • Protease ICH-3
  • Protease TY
  • TY protease

Background

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-5 (ICH-3, ICEREL-III, TY protease) is a member of the caspase-1 subfamily and it is an upstream mediator of apoptosis. Caspase-5 is highly expressed in lung, liver, and skeletal muscle, and similar to Caspase-4, its overexpression can induce cellular apoptosis (1). A tetramer, Caspase-5 separates into two subunits of a 20kda (p20) and 10kda (p10) after activation. In vitro, Caspase-5 can be cleaved by GranB, a major player in Cytotoxic T lymphocytes (CTL) induced apoptosis (2). In vivo, the Caspase-5 expression is elevated by LPS and IFNg. Caspase-5 induced apoptosis can be inhibited by CrmA and Bcl-2. Caspase-5 has also been implicated in cellular inflammatory response and in the microsatelite mutator pathway for cancer (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CASP5