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Bone marrow stromal cell antigen 1/CD157 Antibody

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Conjugate Size Price
Biotin
BAF4710
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Catalog# & Formulation Size Price
Carrier Free
AF4710-SP
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Bone marrow stromal cell antigen 1/CD157 Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CD157
Ala25-Glu285
Accession # Q64277
Specificity
Detects mouse CD157 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human CD157 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
BST1
Purity Statement
Antigen Affinity-purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publication using AF4710.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Bone marrow stromal cell antigen 1/CD157 Antibody

  • ADP-ribosyl cyclase 2
  • Bone marrow stromal antigen 1
  • bone marrow stromal cell antigen 1
  • BP-3
  • BST1
  • BST-1
  • cADPr hydrolase 2
  • CD157 antigen
  • CD157
  • Cyclic ADP-ribose hydrolase 2
  • EC 3.2.2.5
  • NAD(+) nucleosidase

Background

CD157, also known as bone marrow stromal cell antigen 1 (BST-1), is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family (1). CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth (2, 3). Along with CD38, CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities (2). It may play a role in rheumatoid arthritis (RA) due to its enhanced expression in RA‑derived bone marrow stromal cell lines (3). CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule (4).

  1. Hussain, A. M. M. et al. (1998) Protein Express. Purif. 12:133.
  2. Sato, A. et al. (1999) Biochem. J. 337:491.
  3. Kaisho, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91:5325.
  4. Ortolan, E. et al. (2002) Cell Biochem. and Function. 20:309.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Bone marrow stromal cell antigen 1/CD157 Antibody (AF4710)(1)


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Bioinformatics

Gene Symbol BST1
Uniprot