| Reactivity | Hu, Mu, RtSpecies Glossary |
| Applications | WB |
| Clone | 2204C |
| Clonality | Monoclonal |
| Host | Rabbit |
| Conjugate | Unconjugated |
| Additional Information | Recombinant Monoclonal Antibody. |
| Immunogen | Synthetic peptide containing human beta ‑2 Adrenergic R/ADRB2 Accession # P07550 |
| Specificity | Detects human beta ‑2 Adrenergic R/ADRB2 in direct ELISAs. Detects human, mouse, and rat beta ‑2 Adrenergic R/ADRB2 in Western blots. |
| Source | N/A |
| Isotype | IgG |
| Clonality | Monoclonal |
| Host | Rabbit |
| Purity Statement | Protein A or G purified from cell culture supernatant |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
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| Publications |
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| Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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| Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Reconstitution Instructions | Reconstitute at 0.5 mg/mL in sterile PBS. |
Beta-2 adrenoceptor (ADRB2) is a 413 amino acids adrenergic receptor expressed in smooth muscle and metabolic tissues. Beta-adrenergic receptors belong to the seven-transmembrane domain/GPCR family of receptors and mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Activation of ADRB2 induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.
![beta-2 Adrenergic R/ADRB2 Antibody (2204C) [Unconjugated]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "beta-2 Adrenergic R/ADRB2 Antibody (2204C) [Unconjugated]")
Secondary Antibodies |
Isotype Controls |
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