BCMA/TNFRSF17 Antibody (161616) [Fluorescein]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BCMA (B Cell Maturation Antigen), also known as TNFRSF17, is a 22-26 kDa member of the TNFR superfamily. It is a type III transmembrane (TM) protein one that is synthesized as a type I TM protein that has a restricted expression pattern. Among the cells recognized to express BCMA are bone marrow plasma cells (PCs), adipocytes and stratum basale keratinocytes. At least some human BCMA is now known to be N-glycosylated, a modification that affects both its affinity for ligand, and its half-life on the cell surface. Mouse, by contrast, has no potential N-linked site, and any glycosylation would have to be either O-linked, or N-linked through the generation of an alternative splice form. In any case, and although the predicted MW of mouse BCMA is 20 kDa, it appears to run anomalously at 22-26 kDa in SDS-PAGE. Mouse BCMA is 185 amino acids (aa) in length. It contains a long, 115 aa cytoplasmic region and a short 49 aa extracellular domain characterized by two cysteine-rich segments. Ligands for BCMA are trimers, and include APRIL and BAFF homotrimers, plus APRIL:BAFF heterotrimers. In human, BCMA is known to be proteolytically cleaved and released, acting as an antagonist to APRIL AND BAFF signaling; in mouse, it is unclear if cleavage occurs. BCMA activation on PCs promotes PC survival, while on adipocytes, BCMA signaling downregulates adiponectin and leptin production, and on keratinocytes, BCMA ligation induces IL-6 and GM-CSF secretion. Over aa 1-49, mouse BCMA shares 65% and 90% aa sequence identity with human and rat BCMA, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 8 of 8.

Publications using FAB593F	Applications	Species
Pham, HTT;Magez, S;Choi, B;Baatar, B;Jung, J;Radwanska, M; Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis Nature communications 2023-09-05 [PMID: 37669943] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
S Chappaz, K McArthur, L Kealy, CW Law, M Tailler, RM Lane, A Lieschke, ME Ritchie, KL Good-Jacob, A Strasser, BT Kile Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells Cell Reports, 2021-07-20;36(3):109430. 2021-07-20 [PMID: 34289356] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Khan A, Hams E, Floudas A, Sparwasser T, Weaver C, Fallon P PD-L1hi B cells are critical regulators of humoral immunity. Nat Commun, 2015-01-22;6(0):5997. 2015-01-22 [PMID: 25609381] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Park K, Bayles I, Szlachta-McGinn A, Paul J, Boiko J, Santos P, Liu J, Wang Z, Borghesi L, Milcarek C Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response. J Immunol, 2014-09-19;193(9):4663-74. 2014-09-19 [PMID: 25238757] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Uslu K, Coleman A, Allman W, Katsenelson N, Bram R, Alugupalli K, Akkoyunlu M Impaired B cell receptor signaling is responsible for reduced TACI expression and function in X-linked immunodeficient mice. J Immunol, 2014-03-19;192(8):3582-95. 2014-03-19 [PMID: 24646744] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Notley CA, Baker N, Ehrenstein MR Secreted IgM enhances B cell receptor signaling and promotes splenic but impairs peritoneal B cell survival. J. Immunol., 2010-03-05;184(7):3386-93. 2010-03-05 [PMID: 20207998] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Crowley JE, Stadanlick JE, Cambier JC, Cancro MP FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood, 2008-09-12;113(7):1464-73. 2008-09-12 [PMID: 18791164] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Kanswal S, Katsenelson N, Selvapandiyan A, Bram RJ, Akkoyunlu M Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL. J. Immunol., 2008-07-15;181(2):976-90. 2008-07-15 [PMID: 18606649] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array FAB593F

• BCMA/TNFRSF17 Antibodies
• BCMA/TNFRSF17 Lysate
• BCMA/TNFRSF17 Proteins
• BCMA/TNFRSF17 ELISAs
• BCMA/TNFRSF17 Proteins and Enzymes