Bad Antibody

The Bcl-2 family of apoptosis-related genes plays central roles in regulating apoptotic pathways (reviewed in Thomadaki and Scorilas, 2006). Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. In mammals, the family consists of both antiapoptotic (prosurvival) and proapoptotic (prodeath) members. Cellular homeostasis is thought to be dependent on a balance between the actions of antiapoptotic and proapoptotic proteins. Bcl-2 family proteins can be divided into 3 main subfamilies based on their function and the content of their Bcl-2 homology (BH) domains, for example: 1) Antiapoptotic: Bcl-2, Bcl-xL, Bcl-W, A1, and Mcl-1 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-xS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. Antiapoptotic members inhibit cells from undergoing apoptosis, whereas proapoptotic and BH3-only subfamily members promote apoptosis. There are 4 BH domains (1-4) conserved among Bcl-2 family proteins. The BH domains are important for function as well as for heterodimerization between family members. Typical antiapoptotic family members have all four BH domains (1-4), whereas proapoptotic (multidomain) members have BH1, 2 and 3 domains and BH3-only members have only the BH3 domain. Overall, the relative ratio of antiapoptotic and proapoptotic proteins determines the susceptibility of a cell to various apoptotic stimuli. Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Antiapoptotic proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Down syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy. Mouse Bad is 204 amino acid protein and rat Bad is a 205 amino acid protein.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB100-56079

• Bad Antibodies
• Bad ELISA Kits
• Bad Lysates
• Bad Proteins