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B7-H4 Antibody (Millennium patent anti-B7-H4)

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Immobilized human B7 H4 at 2 ug/mL can bind B7-H4 Antibody (Millennium patent anti-B7-H4), EC50=0.07145 ug/mL.
Immobilized human B7 H4 at 2 ug/mL can bind B7-H4 Antibody (Millennium patent anti-B7-H4), EC50=0.07145 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
Millennium patent anti-B7-H4
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-28513AF350
Alexa Fluor 405
NBP3-28513AF405
Alexa Fluor 488
NBP3-28513AF488
Alexa Fluor 532
NBP3-28513AF532
Alexa Fluor 594
NBP3-28513AF594
Alexa Fluor 647
NBP3-28513AF647
Alexa Fluor 700
NBP3-28513AF700
Alexa Fluor 750
NBP3-28513AF750
Allophycocyanin
NBP3-28513APC
Biotin
NBP3-28513B
CoraFluor 1
NBP3-28513CL1
DyLight 350
NBP3-28513UV
DyLight 405
NBP3-28513V
DyLight 488
NBP3-28513G
DyLight 550
NBP3-28513R
DyLight 594
NBP3-28513DL594
DyLight 650
NBP3-28513C
DyLight 680
NBP3-28513FR
DyLight 755
NBP3-28513IR
FITC
NBP3-28513F
HRP
NBP3-28513H
Janelia Fluor 525
NBP3-28513JF525
Janelia Fluor 549
NBP3-28513JF549
Janelia Fluor 646
NBP3-28513JF646
Janelia Fluor 669
NBP3-28513JF669
PE
NBP3-28513PE
PerCP
NBP3-28513PCP
mFluor Violet 450 SE
NBP3-28513MFV450
mFluor Violet 500 SE
NBP3-28513MFV500
mFluor Violet 610 SE
NBP3-28513MFV610
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B7-H4 Antibody (Millennium patent anti-B7-H4) Summary

Description
Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
B7-H4 / VTCN1
Isotype
IgG1
Clonality
Monoclonal
Host
Human
Gene
VTCN1
Purity
Protein A purified
Endotoxin Note
< 0.001EU/ug,determined by LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for B7-H4 Antibody (Millennium patent anti-B7-H4)

  • B7h.5
  • B7H4
  • B7-H4
  • B7H4T-cell costimulatory molecule B7x
  • B7S1
  • B7S1VCTN1
  • B7x
  • B7XPRO1291
  • FLJ22418
  • Immune costimulatory protein B7-H4
  • Protein B7S1
  • T cell costimulatory molecule B7x
  • V-set domain containing T cell activation inhibitor 1
  • V-set domain-containing T-cell activation inhibitor 1
  • Vtcn1

Background

B7H4 is a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7H4 deficient mice are only minimally affected, thus suggesting B7H4 is important in the fine tuning of the T-cell mediated immune response. B7H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC). There are three different isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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B7-H4 Antibody
(Millennium patent an ...
NBP3-28513
B7-H4 Antibody (Millennium patent anti-B7-H4)
Species: Hu
Applications: ELISA, Flow, Func

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Bioinformatics

Gene Symbol VTCN1
Uniprot