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Aurora B Antibody (RM278)

Images

 
Western Blot: Aurora B Antibody (RM278) [NBP2-61493] - Western Blot of HeLa cells nontreated (-) or treated (+) with Nocodazole (NOC), using NBP2-61493 at a 1:1000 dilution
Immunohistochemistry-Paraffin: Aurora B Antibody (RM278) [NBP2-61493] - Immunohistochemical staining of formalin fixed and paraffin embedded Human tonsil tissue sections using NBP2-61493 at a 1:500 dilution

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
RM278
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Aurora B Antibody (RM278) Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
A peptide corresponding to the N-terminus of Human Aurora B
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
AURKB
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200-1:500
  • Immunohistochemistry-Paraffin
  • Western Blot 1:1000 - 1:2000
Publications
Read Publication using NBP2-61493.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
50% Glycerol/PBS, 1% BSA
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for Aurora B Antibody (RM278)

  • Aik2
  • AIK2EC 2.7.11.1
  • AIM1
  • AIM-1
  • AIM1Aik2
  • AIM-1STK-1
  • ARK2
  • ARK2ARK-2
  • AurB
  • AURKB
  • aurkb-sv2
  • Aurora- and IPL1-like midbody-associated protein 1
  • Aurora B
  • aurora kinase BSerine/threonine-protein kinase aurora-B
  • aurora kinase B-Sv1
  • aurora kinase B-Sv2
  • Aurora/IPL1-related kinase 2
  • aurora-1
  • aurora-B
  • Aurora-related kinase 2
  • EC 2.7.11
  • IPL1
  • serine/threonine kinase 12
  • serine/threonine-protein kinase 12
  • STK12
  • STK12aurkb-sv1
  • STK5

Background

Aurora-B is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process. Aurora-B is known to be involved in the regulation of centrosome function, bipolar spindle assembly and chromosome segregation. Aurora kinases are localized at the centrosomes of interphase cells, at the poles of the bipolar spindle and in the midbody of the mitotic apparatus. Substrates identified for the Aurora-B kinases include a kinesin-like motor protein, spindle apparatus proteins, histone H3 protein, kinetochore protein and the tumor suppressor protein p53 (1). Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. Identification of Aurora kinases as RasGAP Src homology 3 domain binding protein, also implicates these kinases as potential effectors in the Ras pathway relevant to oncogenesis (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Aurora B Antibody (NBP2-61493)(1)

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Bioinformatics

Gene Symbol AURKB