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AG-2/AGR2 Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, Mu, BvSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-05936AF350
Alexa Fluor 405
NBP1-05936AF405
Alexa Fluor 488
NBP1-05936AF488
Alexa Fluor 532
NBP1-05936AF532
Alexa Fluor 594
NBP1-05936AF594
Alexa Fluor 647
NBP1-05936AF647
Alexa Fluor 700
NBP1-05936AF700
Alexa Fluor 750
NBP1-05936AF750
Allophycocyanin
NBP1-05936APC
Biotin
NBP1-05936B
CoraFluor 1
NBP1-05936CL1
DyLight 350
NBP1-05936UV
DyLight 488
NBP1-05936G
DyLight 550
NBP1-05936R
DyLight 594
NBP1-05936DL594
DyLight 650
NBP1-05936C
DyLight 680
NBP1-05936FR
DyLight 755
NBP1-05936IR
FITC
NBP1-05936F
HRP
NBP1-05936H
Janelia Fluor 525
NBP1-05936JF525
Janelia Fluor 549
NBP1-05936JF549
Janelia Fluor 635
NBP1-05936JF635
Janelia Fluor 646
NBP1-05936JF646
Janelia Fluor 669
NBP1-05936JF669
PE
NBP1-05936PE
PerCP
NBP1-05936PCP
Unconjugated
NBP1-05936
mFluor Violet 450 SE
NBP1-05936MFV450
mFluor Violet 500 SE
NBP1-05936MFV500
mFluor Violet 610 SE
NBP1-05936MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-05936
BSA Free
NBP1-05936SS
BSA Free
NBP1-05936
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AG-2/AGR2 Antibody [DyLight 405] Summary

Immunogen
Synthetic peptide made to an N-terminal portion of mouse AGR2 (within residues 1-50). [Swiss-Prot# O88312]
Localization
Secreted
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AGR2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for AG-2/AGR2 Antibody [DyLight 405]

  • AG2
  • AG-2
  • AG2member 17
  • AGR2
  • anterior gradient 2 homolog (Xenopus laevis)
  • anterior gradient homolog 2 (Xenopus laevis)
  • GOB-4
  • hAG-2
  • HPC8
  • PDIA17
  • secreted cement gland homolog

Background

Originally discovered in Xenopus laevis wherein it plays a role during early neural development, AGR2 (anterior gradient protein 2 homolog) is now known as a member of protein disulfide isomerase (PDI) family of ER-resident proteins which is expressed in a variety of normal as well as transformed epithelial tissues. AGR2 has been implicated in the folding of proteins as a chaperone protein. It interacts with LYPD3, DAG1 (alphaDAG1) and MUC2 (disulfide-linked), and is essential for MUC2 translation as well as secretion. AGR2 plays a key role in the production of mucus by intestinal cells and has also been suggested to be a proto-oncogene that may involve in cellular migration, differentiation and growth. Differential expression of AGR2 was first found in estrogen receptor (ER)-positive breast cancer cell lines and subsequently, elevated AGR2 levels have been seen in subsets of other cancers also wherein its upregulation enhances classical hallmarks of cancer such as metastasis, invasion, colony formation, and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol AGR2