| Reactivity | HuSpecies Glossary |
| Applications | WB, IP |
| Clonality | Polyclonal |
| Host | Sheep |
| Conjugate | Unconjugated |
| Concentration | LYOPH |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human ADAM22 Gly26-His528 (Leu78Val) Accession # Q9P0K1 |
| Specificity | Detects human ADAM22 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) ADAM8, rhADAM12, and rhADAM33 is observed. |
| Source | N/A |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Sheep |
| Gene | ADAM22 |
| Purity Statement | Antigen Affinity-purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
| Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
| Preservative | No Preservative |
| Concentration | LYOPH |
| Reconstitution Instructions | Reconstitute at 0.2 mg/mL in sterile PBS. |
ADAM22 (a disintegrin and metalloprotease 22; also MDC2) is an 85‑90 kDa member of the M12B peptidase family of enzymes. It is expressed on both neurons and astrocytes in cranial regions of the CNS. The human ADAM22 proprecursor is an 881 amino acid (aa) type I transmembrane protein. It contains a 197 aa cleavable proregion (aa 26‑222) and a 512 aa extracellular domain (ECD) (aa 223‑736). The ECD contains a nonfunctional metalloprotease domain (aa 239‑438), an integrin‑binding disintegrin region (aa 444‑531) and a Cys‑rich domain (aa 532‑678). Multiple splice variants exist, two of which may involve the ECD. Both show premature truncations. One has a 10 aa substitution for aa 234‑906, while a second shows an 11 aa substitution for aa 332‑906. Over aa 26‑528, human ADAM22 is 90% aa identical to mouse ADAM22.
Secondary Antibodies |
Isotype Controls |
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