ADAM22 Products

Description

ADAM22 was first described as MDC2 (Metalloproteinase-like disintergin like cysteine rich 2) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends have been described. ADAM22 participates in cell adhesion and spreading by associating with 14-3-3 proteins. It is constitutively produced in normal brain tissue, but decreased or absent in high grade gliomas. Different splice variants of ADAM22 are differentially expressed in areas of the brain. A complex of ADAM22 and LGI1 were shown to regulate synaptic transmission. Complexes of ADAM22, stargazing, and a range of other proteins anchor ADAM22 into the cytoskeleton, and keep ADAM22 in association with the postsynaptic space. ADAM22 does not contain the canonical HExxHxxxxxH zinc metalloproteinase motif, and is not thought to be proteolytically active. ADAM22 is a member of the ADAMS that function in tandem with other ADAMs and which may also have specific individual functions.

Bioinformatics

Entrez	11496 Mouse 53616 Human 57033 Rat
Uniprot	AAH36029.1 Human Q9P0K1 Human Q9R1V6 Mouse
Product By Gene ID	53616
Alternate Names	ADAM 22 ADAM metallopeptidase domain 22 metalloproteinase-disintegrin ADAM22-3 metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2 MGC149832