Activin A Antibody [Unconjugated] - beta A subunit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Activin and Inhibin are members of the TGF-beta superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis (1‑7). Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfide-linked dimers of the bioactive proteins (8, 9). Activins are nonglycosylated homodimers or heterodimers of various beta subunits ( beta A, beta B, beta C, and beta E in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two beta A chains. The beta A subunit can also heterodimerize with a beta B or beta C subunit to form Activin AB and Activin AC, respectively (10). The 14 kDa mature human beta A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat beta A. Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK-4 (7, 11). Signaling through this receptor complex leads to Smad activation and regulation of activin-responsive gene transcription (7, 11). The bioactivity of Activin A is regulated by a variety of mechanisms (11). BAMBI, Betaglycan, and Cripto are cell-associated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly (12‑14). The intracellular formation of Activin A can be prevented by the incorporation of the beta A subunit into Activin AC or Inhibin A (3, 10). And the bioavailability of Activin A is restricted by its incorporation into inactive complexes with alpha 2-Macroglobulin, Follistatin, and FLRG (15, 16).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Canine, Porcine, Primate - Cholrocebus pygerythrus (Vervet Monkey).

We have publications tested in 11 applications: ELISA Development, Flow Cytometry, Functional Assay, ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry, In Vivo, Neutralization, Western Blot.

Showing Publications 1 - 10 of 35. Show All 35 Publications. Collapse Publications.

Publications using AF338	Applications	Species
Evans, ET;Page, EF;Choi, AS;Shonibare, Z;Kahn, AG;Arend, RC;Mythreye, K; Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer Cancer medicine 2024-09-01 [PMID: 39248018] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Muhamad, SA;Safuan, S;Stanslas, J;Wan Ahmad, WAN;Bushra, SM;Nurul, AA; Lignosus rhinocerotis extract ameliorates airway inflammation and remodelling via attenuation of TGF-?1 and Activin A in a prolonged induced allergic asthma model Scientific reports 2023-10-27 [PMID: 37891170] (IHC, Mouse)	IHC	Mouse
Penny A. F. Whiley, Michael C. M. Luu, Liza O'Donnell, David J. Handelsman, Kate L. Loveland Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure Front Endocrinol (Lausanne) 2023-09-01 [PMID: 37727456]
J Xu, L Zhang, M Li, X He, J Luo, R Wu, Z Hong, H Zheng, X Hu TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair Journal of Neuroinflammation, 2023-02-25;20(1):50. 2023-02-25 [PMID: 36829205] (Neutralization, Rat)	Neutralization	Rat
H Sugii, MS Albougha, O Adachi, H Tomita, A Tomokiyo, S Hamano, D Hasegawa, S Yoshida, T Itoyama, H Maeda Activin A Promotes Osteoblastic Differentiation of Human Preosteoblasts through the ALK1-Smad1/5/9 Pathway International Journal of Molecular Sciences, 2021-12-16;22(24):. 2021-12-16 [PMID: 34948289] (ICC, IHC, Human, Rat)	ICC, IHC	Human, Rat
Christina Mundy, Lutian Yao, Sayantani Sinha, Juliet Chung, Danielle Rux, Sarah E. Catheline et al. Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice Science Signaling 2021-02-10 [PMID: 33563697]
CT Werner, S Mitra, BD Auerbach, ZJ Wang, JA Martin, AF Stewart, PH Gobira, M Iida, C An, MM Cobb, A Caccamise, RJ Salvi, RL Neve, AM Gancarz, DM Dietz Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence Proc Natl Acad Sci U S A, 2020-10-05;0(0):. 2020-10-05 [PMID: 33020308] (In Vivo, Mouse)	In Vivo	Mouse
AL Thomas, K Castellano, G Mancinelli, Y Xia, J Bauer, C Yazici, G Fantuzzi, RF Hwang, NL Krett, GI Papachrist, DC Whitcomb, B Jung Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index Clin Transl Gastroenterol, 2020-05-01;11(5):e00152. 2020-05-01 [PMID: 32358238] (In Vivo, Mouse)	In Vivo	Mouse
Xiaoling Zhong, Marianne Pons, Christophe Poirier, Yanlin Jiang, Jianguo Liu, George E. Sandusky et al. The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy Journal of Cachexia, Sarcopenia and Muscle 2019-10-01 [PMID: 31286691]
A Lepletier, ML Hun, MV Hammett, K Wong, H Naeem, M Hedger, K Loveland, AP Chidgey Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging Cell Rep, 2019-06-25;27(13):3887-3901.e4. 2019-06-25 [PMID: 31242421] (Functional Assay, Mouse)	Functional Assay	Mouse
Q Jin, C Qiao, J Li, B Xiao, J Li, X Xiao A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice Skelet Muscle, 2019-05-27;9(1):16. 2019-05-27 [PMID: 31133057] (Western Blot, Human)	Western Blot	Human
Régis P. Lemaitre, Aliona Bogdanova, Barbara Borgonovo, Jeffrey B. Woodruff, David N. Drechsel FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing BMC Biotechnology 2019-12-01 [PMID: 30925874]
Melissa LaBonty, Nicholas Pray, Pamela C. Yelick Injury of Adult Zebrafish Expressing Acvr1lQ204D Does Not Result in Heterotopic Ossification Zebrafish 2018-12-01 [PMID: 30183553]
AL Carlton, A Illendula, Y Gao, DC Llaneza, A Boulton, A Shah, RA Rajewski, CN Landen, D Wotton, JH Bushweller Small molecule inhibition of the CBF?/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition Gynecol. Oncol., 2018-03-16;0(0):. 2018-03-16 [PMID: 29551565] (ICC, Human)	ICC	Human
J Hu, X Wang, YH Tang, YG Shan, Q Zou, ZQ Wang, CX Huang Activin A inhibition attenuates sympathetic neural remodeling following myocardial infarction in rats Mol Med Rep, 2018-01-25;17(4):5074-5080. 2018-01-25 [PMID: 29393433] (IHC-P, Western Blot, Rat)	IHC-P, Western Blot	Rat
Jonas J Staudacher, Cemal Yazici, Timothy Carroll, Jessica Bauer, Jingbo Pang, Nancy Krett, Yinglin Xia, Annette Wilson, Georgios Papachris, Andrea Dirmeier, Claudia Kunst, David C Whitcomb, Giamila Fantuzzi, Barbara Jung Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target. Scientific Reports, 2017-10-06;0(0):2045-2322. 2017-10-06 [PMID: 28986573] (In Vivo, Mouse)	In Vivo	Mouse
SA Samant, A Kanwal, VB Pillai, R Bao, MP Gupta The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy Sci Rep, 2017-09-19;7(1):11877. 9/19/2017 [PMID: 28928419]
C Wallner, H Jaurich, JM Wagner, M Becerikli, K Harati, M Dadras, M Lehnhardt, B Behr Inhibition of GDF8 (Myostatin) accelerates bone regeneration in diabetes mellitus type 2 Sci Rep, 2017-08-29;7(1):9878. 2017-08-29 [PMID: 28852138] (Neutralization, Mouse)	Neutralization	Mouse
S Merfeld-Cl, H Lu, X Wu, KL March, DO Traktuev Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity J. Cell. Mol. Med., 2017-08-18;0(0):. 2017-08-18 [PMID: 28834227] (Neutralization, Human)	Neutralization	Human
Mohsin Bashir, Surekha Damineni, Geetashree Mukherjee, Paturu Kondaiah Activin-A signaling promotes epithelial–mesenchymal transition, invasion, and metastatic growth of breast cancer npj Breast Cancer 2015-08-12 [PMID: 28721365]
Ze-Yang Ding, Guan-Nan Jin, Wei Wang, Yi-Min Sun, Wei-Xun Chen, Lin Chen et al. Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells International Journal of Molecular Sciences 2016-03-22 [PMID: 27011166]
Yang Y, Zhang N, Crombruggen K, Lan F, Hu G, Hong S, Bachert C Differential Expression and Release of Activin A and Follistatin in Chronic Rhinosinusitis with and without Nasal Polyps. PLoS ONE, 2015-06-01;10(6):e0128564. 2015-06-01 [PMID: 26030615] (IHC-Fr, Human)	IHC-Fr	Human
Stelios Vittorakis, Konstantinos Samitas, Sofia Tousa, Eleftherios Zervas, Maria Aggelakopoulou, Maria Semitekolou et al. Circulating conventional and plasmacytoid dendritic cell subsets display distinct kinetics during in vivo repeated allergen skin challenges in atopic subjects BioMed Research International 2014-04-28 [PMID: 24877070]
Dussiot M, Maciel T, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil J, Arlet J, Cote F, Courtois G, Ginzburg Y, Daniel T, Chopra R, Sung V, Hermine O, Moura I An activin receptor IIA ligand trap corrects ineffective erythropoiesis in beta-thalassemia. Nat Med, 2014-03-23;20(4):398-407. 2014-03-23 [PMID: 24658077] (ELISA Development, Flow Cytometry, ICC, IHC-P, Neutralization, Human, Mouse)	ELISA Development, Flow Cytometry, ICC, IHC-P, Neutralization	Human, Mouse
Yaden B, Wang Y, Wilson J, Culver A, Milner A, Datta-Mannan A, Shetler P, Croy J, Dai G, Krishnan V Inhibition of activin A ameliorates skeletal muscle injury and rescues contractile properties by inducing efficient remodeling in female mice. Am J Pathol, 2014-04-01;184(4):1152-66. 2014-04-01 [PMID: 24655377] (ELISA Development, Mouse)	ELISA Development	Mouse
Chen L, Zhang W, Liang H, Zhou Q, Ding Z, Yang H, Liu W, Wu Y, Man Q, Zhang B, Chen X Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells. Cell Commun Signal, 2014-03-17;12(0):18. 2014-03-17 [PMID: 24628936] (IHC-P, Rat)	IHC-P	Rat
Seeger P, Bosisio D, Parolini S, Badolato R, Gismondi A, Santoni A, Sozzani S Activin A as a mediator of NK-dendritic cell functional interactions. J Immunol, 2014-01-06;192(3):1241-8. 2014-01-06 [PMID: 24395917] (Neutralization, Human)	Neutralization	Human
Veronique E. Miron, Amanda Boyd, Jing-Wei Zhao, Tracy J. Yuen, Julia M. Ruckh, Jennifer L. Shadrach et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination Nature Neuroscience 2013-09-01 [PMID: 23872599]
Michael Bordonaro, Shruti Tewari, Wafa Atamna, Darina L. Lazarova The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways Experimental Cell Research 2011-06-10 [PMID: 21473864]
Zucchini S, Buzzi A, Barbieri M, Rodi D, Paradiso B, Binaschi A, Coffin JD, Marzola A, Cifelli P, Belluzzi O, Simonato M Fgf-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss. J. Neurosci., 2008-12-03;28(49):13112-24. 2008-12-03 [PMID: 19052202] (IHC-P, Mouse)	IHC-P	Mouse
Lin J, Patel SR, Wang M, Dressler GR The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Mol. Cell. Biol., 2006-06-01;26(12):4577-85. 2006-06-01 [PMID: 16738323] (Western Blot, Mouse)	Western Blot	Mouse
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Neutralization, Western Blot, Rat)	Neutralization, Western Blot	Rat
Barksby HE, Hui W, Wappler I, Peters HH, Milner JM, Richards CD, Cawston TE, Rowan AD Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair. Arthritis Rheum., 2006-02-01;54(2):540-50. 2006-02-01 [PMID: 16447230] (IHC-P, Human)	IHC-P	Human
Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, Savitsky K, Rotman G hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene, 2004-04-28;331(0):17-31. 2004-04-28 [PMID: 15094188] (Western Blot, Primate - Cholrocebus pygerythrus (Vervet Monkey))	Western Blot	Primate - Cholrocebus pygerythrus (Vervet Monkey)
Yamashita S, Maeshima A, Kojima I, Nojima Y Activin A is a potent activator of renal interstitial fibroblasts. J. Am. Soc. Nephrol., 2004-01-01;15(1):91-101. 2004-01-01 [PMID: 14694161] (ICC, Canine, Porcine, Rat)	ICC	Canine, Porcine, Rat
Show All 35 Publications. Collapse Publications.

Array AF338

• Activin A Antibodies
• Activin A Lysate
• Activin A Protein
• Activin A Proteins and Enzymes
• Activin A ELISAs