Aconitase 1 Antibody

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP1-51965	Applications	Species
Wang W, Di X, D'Agostino RB et al. Excess capacity of the iron regulatory protein system. J Biol Chem 2007-08-01 [PMID: 17604281]

Array NBP1-51965

• Aconitase 1 Antibodies
• Aconitase 1 ELISA Kit
• Aconitase 1 Lysate
• Aconitase 1 Proteins