Aconitase 1 Products

Description

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Bioinformatics

Entrez	11428 Mouse 48 Human 50655 Rat
Uniprot	AAH18103 Human NM_002197 Human NP_002188 Human NP_002188.1 Human P21399 Human
Product By Gene ID	48
Alternate Names	aconitase 1, soluble Aconitase aconitate hydratase Citrate hydro-lyase cytoplasmic aconitate hydratase EC 4.2.1 EC 4.2.1.3 Ferritin repressor protein IREB1IREBP1 IRE-BP 1 IREBP Iron regulatory protein 1 iron-responsive element binding protein 1 Iron-responsive element-binding protein 1 IRP1ACONS