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![Western Blot: TDG Antibody (3C11) [NBP2-46091] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDG.](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Western-Blot-NBP2-46091-img0014.jpg "Western Blot: TDG Antibody (3C11) [NBP2-46091] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDG.")
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Human tonsil tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0013.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Human colon tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0001.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Adenocarcinoma of Human colon tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0002.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Carcinoma of Human kidney tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0003.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Human pancreas tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0004.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Human thyroid tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0005.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0006.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Adenocarcinoma of Human endometrium tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0007.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Human prostate tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0008.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Carcinoma of Human prostate tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0009.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Human bladder tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0010.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Human lymph node tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0011.jpg)
![Immunohistochemistry: TDG Antibody (3C11) [NBP2-46091] - Analysis of Human lymphoma tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](http://images.novusbio.com/fullsize/TDG-Antibody-3C11-Immunohistochemistry-NBP2-46091-img0012.jpg)
![Knockout Validated: TDG Antibody [NBP2-20627] - Wild-type (WT) and TDG knockout (KO) HeLa cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with TDG antibody. HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.](http://images.novusbio.com/fullsize/TDG-Antibody-Western-Blot-NBP2-20627-img0006.jpg "<b>Genetic Strategies Validation. </b>Knockout Validated: TDG Antibody [NBP2-20627] - Wild-type (WT) and TDG knockout (KO) HeLa cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with TDG antibody. HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.")
![<b>Genetic Strategies Validation. </b>Immunocytochemistry/Immunofluorescence: TDG Antibody [NBP2-20627] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: TDG protein stained by TDG antibody diluted at 1:1000. Blue: Hoechst 33342 staining.](http://images.novusbio.com/fullsize/TDG-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-20627-img0005.jpg)
![Western Blot: TDG Antibody [NBP2-20627] - Non-transfected (-) and transfected (+) 293T whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with TDG antibody (NBP2-20627) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.](http://images.novusbio.com/fullsize/nbp2-20627_rabbit-polyclonal-tdg-antibody-9102024206333.jpg)
![Western Blot: TDG Antibody [NBP2-20627] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with TDG antibody (NBP2-20627) diluted at 1:500.](http://images.novusbio.com/fullsize/nbp2-20627_rabbit-polyclonal-tdg-antibody-910202420122027.jpg)
![<b>Genetic Strategies Validation. </b>Western Blot: TDG Antibody [NBP2-20627] - Wild-type (WT) and TDG knockout (KO) HeLa cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with TDG antibody diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.](http://images.novusbio.com/fullsize/nbp2-20627_rabbit-polyclonal-tdg-antibody-1610202419414545.jpg)
![Western Blot: TDG Antibody [NBP2-32248] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-Thymine DNA glycosylase antibody NBP2-32248 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.](http://images.novusbio.com/fullsize/TDG-Antibody-Western-Blot-NBP2-32248-img0001.jpg "<b>Biological Strategies Validation. </b>Western Blot: TDG Antibody [NBP2-32248] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-Thymine DNA glycosylase antibody NBP2-32248 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.")
![<b>Biological Strategies Validation. </b>Immunohistochemistry-Paraffin: TDG Antibody [NBP2-32248] - FFPE section of human lung cancer. Antibody: Affinity purified rabbit anti- TDG used at a dilution of 1:1,000 (1ug/ml). Detection: DAB](http://images.novusbio.com/fullsize/TDG-Antibody-Immunohistochemistry-NBP2-32248-img0004.jpg)
![Immunohistochemistry-Paraffin: TDG Antibody [NBP2-32248] - FFPE section of human mammary glands. Antibody: Affinity purified rabbit anti- TDG used at a dilution of 1:1,000 (1ug/ml). Detection: DAB](http://images.novusbio.com/fullsize/TDG-Antibody-Immunohistochemistry-NBP2-32248-img0003.jpg)
![Immunoprecipitation: TDG Antibody [NBP2-32248] - Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from 293T cells. Antibodies: Affinity purified rabbit anti-Thymine DNA glycosylase antibody NBP2-32248 used for IP at 6 ug per reaction. Thymine DNA glycosylase was also immunoprecipitated by rabbit anti-Thymine DNA glycosylase antibody BL16331. For blotting immunoprecipitated Thymine DNA glycosylase, NBP2-32248 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.](http://images.novusbio.com/fullsize/TDG-Antibody-Immunoprecipitation-NBP2-32248-img0002.jpg)
![Western Blot: TDG Antibody (1511) [NBP2-43718] - Analysis of 293T mock transfected (-) or transfected with a construct expressing human TDG. 10 % SDS-PAGE TDG antibody dilution: 1:10000.](http://images.novusbio.com/fullsize/TDG-Antibody-1511-Western-Blot-NBP2-43718-img0001.jpg "Western Blot: TDG Antibody (1511) [NBP2-43718] - Analysis of 293T mock transfected (-) or transfected with a construct expressing human TDG. 10 % SDS-PAGE TDG antibody dilution: 1:10000.")
![Immunohistochemistry-Paraffin: TDG Antibody (1511) [NBP2-43718] - TDG antibody detects TDG protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded mouse heart. TDG stained by TDG antibody diluted at 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](http://images.novusbio.com/fullsize/TDG-Antibody-1511-Immunohistochemistry-Paraffin-NBP2-43718-img0004.jpg)
![Immunohistochemistry-Paraffin: TDG Antibody (1511) [NBP2-43718] - TDG antibody detects TDG protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded rat intestine. TDG stained by TDG antibody diluted at 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](http://images.novusbio.com/fullsize/TDG-Antibody-1511-Immunohistochemistry-Paraffin-NBP2-43718-img0002.jpg)
![Immunohistochemistry-Paraffin: TDG Antibody (1511) [NBP2-43718] - TDG antibody detects TDG protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded rat prostate. TDG stained by TDG antibody diluted at 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](http://images.novusbio.com/fullsize/TDG-Antibody-1511-Immunohistochemistry-Paraffin-NBP2-43718-img0003.jpg)
![Immunocytochemistry/Immunofluorescence: TDG Antibody [NBP2-13423] - Staining of human cell line HeLa shows localization to nucleoplasm. Antibody staining is shown in green.](http://images.novusbio.com/fullsize/TDG-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-13423-img0007.jpg "Immunocytochemistry/Immunofluorescence: TDG Antibody [NBP2-13423] - Staining of human cell line HeLa shows localization to nucleoplasm. Antibody staining is shown in green.")
![Immunohistochemistry-Paraffin: TDG Antibody [NBP2-13423] - Staining of human cerebellum shows strong nuclear positivity in Purkinje cells.](http://images.novusbio.com/fullsize/TDG-Antibody-Immunohistochemistry-Paraffin-NBP2-13423-img0001.jpg)
![Western Blot: TDG Antibody (311) [NBP2-43802] - Analysis of Non-transfected (-) and TDG -transfected (+, ) 293T whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with TDG antibody diluted by 1:2500.](http://images.novusbio.com/fullsize/TDG-Antibody-311-Western-Blot-NBP2-43802-img0001.jpg "Western Blot: TDG Antibody (311) [NBP2-43802] - Analysis of Non-transfected (-) and TDG -transfected (+, ) 293T whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with TDG antibody diluted by 1:2500.")
![Immunohistochemistry-Paraffin: TDG Antibody (311) [NBP2-43802] - TDG antibody detects TDG protein at nucleus by immunohistochemical analysis.Sample: Paraffin-embedded mouse brain. TDG stained by TDG antibody diluted at 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min](http://images.novusbio.com/fullsize/TDG-Antibody-311-Immunohistochemistry-Paraffin-NBP2-43802-img0002.jpg)
![Western Blot: TDG Antibody (311) [NBP2-43802] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with TDG antibody [GT311] (NBP2-43802) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.](http://images.novusbio.com/fullsize/nbp2-43802_mouse-monoclonal-tdg-antibody-311-910202419593596.jpg)
![Western Blot: TDG Antibody (1142) [NBP2-43595] - Analysis of Non-transfected (-) and TDG -transfected (+, ) 293T whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with TDG antibody diluted by 1:2500.](http://images.novusbio.com/fullsize/TDG-Antibody-1142-Western-Blot-NBP2-43595-img0001.jpg "Western Blot: TDG Antibody (1142) [NBP2-43595] - Analysis of Non-transfected (-) and TDG -transfected (+, ) 293T whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with TDG antibody diluted by 1:2500.")
![Immunocytochemistry/Immunofluorescence: TDG Antibody (1142) [NBP2-43595] - Analysis of Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: TDG protein stained by TDG antibody [1142] diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 um.](http://images.novusbio.com/fullsize/TDG-Antibody-1142-Immunocytochemistry-Immunofluorescence-NBP2-43595-img0003.jpg)
![Western Blot: TDG Antibody (622) [NBP2-43717] - RNAseq analysis showed that essential factors of the BER pathway were statistically significantly down-regulated (p<0.05) in 96-h induced Saos2- (i) and Li-Fraumeni- (ii) p21WAF1/Cip1 Tet-ON cells (see also Additional file 1: Figure S3 for specific real time RT-PCR validation). Note that although in Saos2- p21WAF1/Cip1 Tet-ON cells OGG1 expression was not found by RNAseq analysis, specific real-time RT-PCR and microarray analysis (see also Additional file 1: Figure S3) [9] confirmed its decreased expression. Selective immunoblots for APEX1, LIG3, TDG, and MUTY confirmed the specificity of the RNA analysis results. a-Tubulin served as loading control. Image collected and cropped by CiteAb from the following publication (genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1401-9), licensed under a CC-BY license.](http://images.novusbio.com/fullsize/TDG-Antibody-622-Western-Blot-NBP2-43717-img0002.jpg "Western Blot: TDG Antibody (622) [NBP2-43717] - RNAseq analysis showed that essential factors of the BER pathway were statistically significantly down-regulated (p<0.05) in 96-h induced Saos2- (i) and Li-Fraumeni- (ii) p21WAF1/Cip1 Tet-ON cells (see also Additional file 1: Figure S3 for specific real time RT-PCR validation). Note that although in Saos2- p21WAF1/Cip1 Tet-ON cells OGG1 expression was not found by RNAseq analysis, specific real-time RT-PCR and microarray analysis (see also Additional file 1: Figure S3) [9] confirmed its decreased expression. Selective immunoblots for APEX1, LIG3, TDG, and MUTY confirmed the specificity of the RNA analysis results. a-Tubulin served as loading control. Image collected and cropped by CiteAb from the following publication (genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1401-9), licensed under a CC-BY license.")
![Western Blot: TDG Antibody (622) [NBP2-43717] - Analysis of 293T mock transfected (-) or transfected with a construct expressing human TDG. 10 % SDS-PAGE TDG antibody dilution: 1:10000.](http://images.novusbio.com/fullsize/TDG-Antibody-622-Western-Blot-NBP2-43717-img0001.jpg)
![Western Blot: TDG Antibody (2F7) [NBP2-22589] - The cell lysates of HeLa (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TDG antibody (1:250). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.](http://images.novusbio.com/fullsize/DGCR8-Antibody-2F7-Western-Blot-NBP2-22589-img0001.jpg "Western Blot: TDG Antibody (2F7) [NBP2-22589] - The cell lysates of HeLa (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TDG antibody (1:250). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.")
![SDS-Page: Recombinant Human TDG Protein [NBP2-22863]](http://images.novusbio.com/fullsize/Recombinant-Human-TDG-Protein-SDS-Page-NBP2-22863-img0002.jpg "SDS-Page: Recombinant Human TDG Protein [NBP2-22863]")
![Western Blot: Thymine DNA glycosylase Overexpression Lysate (Adult Normal) [NBL1-16797] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Thymine DNA glycosylase.](http://images.novusbio.com/fullsize/Thymine-DNA-glycosylase-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-16797-img0002.jpg "Western Blot: Thymine DNA glycosylase Overexpression Lysate (Adult Normal) [NBL1-16797] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Thymine DNA glycosylase.")