Species: Hu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Rb
Applications: WB, ELISA, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. In brain, more than 90% of cAMP formed by the stimulation of GPCRs is hydrolyzed by PDE4 enzymes. PDE4 enzymes are also important molecular targets for a variety of therapeutic agents like antidepressants, anti-asthmatics, and anti-inflammatory drugs. PDE4 family comprises 4 genes (PDE4A, B, C and D); each exhibiting multiple isozymes due to alternate splicing that leads to a larger number of distinct PDE4 variants. Members of the PDE4 family are regulated/activated by phosphorylation/dephosphorylation by cAMP-dependent protein kinase A and phosphatases. Protein-protein interactions and cellular trafficking of PDE4A enzymes play an important role in cAMP compartmentalization and cAMP-dependent signaling. In brain members of the PDE4A, B and D family are associated with GPCRs (adrenergic and dopaminergic) signaling.
Bioinformatics
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
5141 |
| Alternate Names |
- cAMP-specific 3'-5'-cyclic phosphodiesterase 4A
- DPDE2cAMP-specific phosphodiesterase
- EC 3.1.4
- EC 3.1.4.17
- PDE4
- PDE46
- phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E2)
- phosphodiesterase 4A, cAMP-specific (dunce
- phosphodiesterase 4A, cAMP-specific
- phosphodiesterase E2 dunce homolog, Drosophila
- phosphodiesterase isozyme 4
|
![Western Blot Phosphodiesterase 4A/PDE4A [p Ser686, p Ser688] Antibody](http://images.novusbio.com/fullsize/Phosphodiesterase-4A-PDE4A-[p-Ser686--p-Ser688]-Antibody-Western-Blot-NB300-635-img0001.jpg)
