Home » Phosphodiesterase 4A/PDE4A » PDE4A Antibodies » Phosphodiesterase 4A/PDE4A Antibody (OTI1C8) [CoraFluor™ 1]
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Phosphodiesterase 4A/PDE4A Antibody (OTI1C8) [CoraFluor™ 1]

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, CyTOF-ready
Clone
OTI1C8
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-73376AF350
Alexa Fluor 405
NBP2-73376AF405
Alexa Fluor 488
NBP2-73376AF488
Alexa Fluor 532
NBP2-73376AF532
Alexa Fluor 594
NBP2-73376AF594
Alexa Fluor 647
NBP2-73376AF647
Alexa Fluor 700
NBP2-73376AF700
Alexa Fluor 750
NBP2-73376AF750
Allophycocyanin
NBP2-73376APC
Allophycocyanin/Cy7
NBP2-73376APCCY7
Biotin
NBP2-73376B
DyLight 350
NBP2-73376UV
DyLight 405
NBP2-73376V
DyLight 488
NBP2-73376G
DyLight 550
NBP2-73376R
DyLight 594
NBP2-73376DL594
DyLight 650
NBP2-73376C
DyLight 680
NBP2-73376FR
DyLight 755
NBP2-73376IR
FITC
NBP2-73376F
HRP
NBP2-73376H
Janelia Fluor 525
NBP2-73376JF525
Janelia Fluor 549
NBP2-73376JF549
Janelia Fluor 646
NBP2-73376JF646
Janelia Fluor 669
NBP2-73376JF669
PE
NBP2-73376PE
PE/Atto594
NBP2-73376PEATT594
PE/Cy5.5
NBP2-73376PECY55
PE/Cy7
NBP2-73376PECY7
PerCP
NBP2-73376PCP
Unconjugated
NBP2-02559
mFluor Violet 450 SE
NBP2-73376MFV450
mFluor Violet 500 SE
NBP2-73376MFV500
mFluor Violet 610 SE
NBP2-73376MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-02559
Azide and BSA Free
NBP2-73376
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Phosphodiesterase 4A/PDE4A Antibody (OTI1C8) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
Full length human recombinant protein of human PDE4A (NP_006193) produced in HEK293T cell.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PDE4A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Phosphodiesterase 4A/PDE4A Antibody (OTI1C8) [CoraFluor™ 1]

  • cAMP-specific 3'-5'-cyclic phosphodiesterase 4A
  • DPDE2
  • DPDE2cAMP-specific phosphodiesterase
  • EC 3.1.4
  • EC 3.1.4.17
  • PDE4
  • PDE46
  • PDE4A
  • Phosphodiesterase 4A
  • phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E2)
  • phosphodiesterase 4A, cAMP-specific (dunce
  • phosphodiesterase 4A, cAMP-specific
  • phosphodiesterase E2 dunce homolog, Drosophila
  • phosphodiesterase isozyme 4

Background

Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. In brain, more than 90% of cAMP formed by the stimulation of GPCRs is hydrolyzed by PDE4 enzymes. PDE4 enzymes are also important molecular targets for a variety of therapeutic agents like antidepressants, anti-asthmatics, and anti-inflammatory drugs. PDE4 family comprises 4 genes (PDE4A, B, C and D); each exhibiting multiple isozymes due to alternate splicing that leads to a larger number of distinct PDE4 variants. Members of the PDE4 family are regulated/activated by phosphorylation/dephosphorylation by cAMP-dependent protein kinase A and phosphatases. Protein-protein interactions and cellular trafficking of PDE4A enzymes play an important role in cAMP compartmentalization and cAMP-dependent signaling. In brain members of the PDE4A, B and D family are associated with GPCRs (adrenergic and dopaminergic) signaling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Phosphodiesterase
4A/PDE4A Antibody (OT ...
NBP2-73376CL1
Phosphodiesterase 4A/PDE4A Antibody (OTI1C8) [CoraFluor™ 1]
Species: Hu, Rt
Applications: WB, Flow, ICC/IF, IHC, CyTOF-ready

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Bioinformatics

Gene Symbol PDE4A