GADD153/CHOP Products

Description

GADD153 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Bioinformatics

Entrez	13198 Mouse 1649 Human 29467 Rat 3553 Human
Uniprot	AAH03637 Human AAH03637.1 Human NM_004083 Human NP_004074 Human P01584 Human P35638 Human P35639 Mouse
Product By Gene ID	1649
Alternate Names	C/EBP-homologous protein 10 C/EBP-homologous protein CCAAT/enhancer-binding protein homologous protein CHOP10 CEBPZ CHOP-10 CHOPC/EBP zeta DDIT-3 DNA damage-inducible transcript 3 protein DNA-damage-inducible transcript 3 GADD153 Growth arrest and DNA damage-inducible protein GADD153

Research Areas for GADD153/CHOP

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Cycle and Replication
DNA Repair
Hypoxia
Lipid and Metabolism
Neuroscience
Unfolded Protein Response