CD81 Products

Description

CD81/TAPA-1 is an integral membrane protein expressed on a variety of cell types, and has a high degree of sequence homology between human and mouse. (1) CD81 is expressed on thymic stromal cells where it plays an important role in the transition of gamma delta + T cells to more mature T cells with alpha beta T cell receptors. (2) Immunohistochemical staining has revealed that its expression is localized to the subcapsular region of the thymus and, specifically, on cells that have distinct clustering patterns. It has been speculated that the ligand for CD81 is the pre-T cell receptor, which is composed of a TCR beta chain and glycoprotein pT alpha. (2) The monoclonal antibody 2F7 can block thymocyte interaction with CD81 in vitro. (2)

Bioinformatics

Entrez	12520 Mouse 25621 Rat 975 Human
Uniprot	AAH02978 Human ABM85948.1 Human NP_004347 Human P35762 Mouse P60033 Human
Product By Gene ID	975
Alternate Names	CD81 antigen (target of antiproliferative 1) CD81 antigen CD81 molecule CVID6 TAPA1 TAPA-1 Target of the antiproliferative 1 Tetraspanin-28 Tspan-28 tspan-28,26 kDa cell surface protein TAPA-1 TSPAN28S5.7

Research Areas for CD81

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cell Cycle and Replication
Immunology

Related CD81 Blog Posts

Check out the latest blog posts on CD81.

Tools for Isolation, Quantification and Analysis of Exosomes Exosomes are spherical to cup-shaped bilayered membrane enclosed nanosize vesicles (30-100 nm) which have the ability to shuttle active cargoes between cells. Johnstone et al. 1987 pioneered in documenting the generation of exosomes in differentiat...    Read more.

CD81/TAPA1: I'm on Tapa the Cell Target of the antiproliferative 1 (TAPA1), also known as CD81, is found in the plasma membrane in lymphocytes and plays an important role in the regulation of lymphoma cell growth. This transmembrane 4 superfamily (TM4SF) protein is primarily found on...    Read more.

Glypican 3 as a biomarker for gastro-esophageal adenocarcinoma By Jamshed Arslan, Pharm. D., PhD. Gastroesophageal adenocarcinoma originates from the glandular epithelium of the esophagus, gastroesophageal junction and stomach. The incidence of gastroesophageal adenocarcinoma is ...    Read more.

CD19: An Undoubted Biomarker for B Cells CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t...    Read more.

Read more CD81 related blogs.