Antibody suppliers

Stem cell marker antibodies are used to identify and isolate stem cells in vitro. Whereas adult stem cells can only differentiate into one cell type, embryonic stem cells (ESCs) have the unique ability to differentiate into a large variety. Stem cells can be genetically manipulated into specific cell lines, and researchers have recently developed a promising new method of producing ESC-like cell lines from adult stem cells.

We at Novus Biologicals have a large antibody database for cancer research. However, AML, or acute myeloid leukaemia, is one of the cancers for which the number of antibodies is still fairly small, owing to limited knowledge of the genes involved.

The Novus Product Development Team is excited to announce the launch of a new antibody target not currently available by any other antibody suppliers. The two new antibodies, a human TMEM97 antibody (NBP1-30436) and mouse TMEM97 antibody (NBP1-30437) are of particular interest as TMEM97 is implicated in several cancers, including breast, pancreatic, colorectal and ovarian cancers.

In the body, plasma B-cells produce large numbers of antibodies specific to foreign proteins. In the 1970s, studies into multiple myeloma (a B-cell cancer) revealed these plasma cells produced an antibody specific to one protein. This led to development of other antigen-specific antibodies.

Antibody suppliers have seen an enormous growth in the area of DNA repair in recent years. DNA damage causes structural changes within the cell that can cause genome mutations to occur, a common cause of tumour development and an important area of research for antibody suppliers like us at Novus Biologicals.

FANCD2 is one of a number of proteins in the FANC group. It undergoes modification in both its normal and disease state; therefore our FANCD2 antibodies are modified and conjugated in various ways for research.

FANCD2 (Fanconi Anaemia Complementation Group D2) is one of several FANC proteins involved with development of Fanconi Anaemia, a genetic disease that increases cell susceptibility to tumour development. In its normal pathway it interacts with several other genes known to cause cancer, for example BRCA1.

DNA repair processes allow cells to identify and correct lesions in the DNA helix. It is normal for these lesions to happen. Environmental processes such as exposure to UV light and chemicals, as well as day-to-day metabolic changes, can cause hundreds of thousands in a day.

Not everyone knows how antibodies influence animal life, so this article is, in part, a very brief introduction. Novus Biologicals offers a printed version of their Apoptosis Catalog that contains additional information on apoptotic mechanisms; email promotions@novusbio.com to get a copy.

We have seen that antibody research can deliver progress in areas where other methods have not enjoyed such success.

Autism is a condition which demands more research - even if some autistic people do not want their condition to be ‘cured’, most would like some of their symptoms to be alleviated.

Fatemi and colleagues (J Autism Dev Disord. 2009, 39(2) pp. 223–230) subjected brain tissue from autistic and control subjects to SDS-PAGE followed by Western blotting and incubation with antibodies to four GABA-A receptor subunits.