The jumonji (JMJ) gene, obtained by a gene trap strategy, is essential for embryogenesis and is suggested to play important roles in cell growth during development. The amino acid sequence of the JMJ protein includes a nuclear localization signal and a DNA binding motif called the AT-rich interactive domain (ARID). Unlike the other members of the JARID family of proteins, JARID2 has a long N-terminal moiety devoid of characterized domains.
Epigenetic alterations have come to prominence in biomedical research. In particular, hypermethylation of CpG islands located in the promoter regions of tumor-suppressor genes is now firmly established as an important mechanism for gene inactivation in cancer.
Embryonic stem (ES) cells are cells derived from the inner cell mass of the blastocyst, an early-stage embryo. ES cells are distinguished from other cells due to their pluripotency, which is the ability to differentiate into any different type of cell in the body, and also their capability of propagating indefinitely. These two factors make embryonic stem cells valuable tools in the scientific community, especially in regenerative medicine.
SOX2 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which play a vital role in embryonic development. SOX2 antibody research has identified Sox2 as a key transcription factor in pluripotent stem cells. We at Novus Biologicals offer a number of top quality SOX2 products in our stem cell antibody catalog.
Embryonic stem cells, embryonic germ cells and teratocarcinoma stem cells are fundamental to understanding early embryo development and differentiation. Therefore, antibodies to embryonic cell surface antigens have emerged as powerful tools for characterizing the function and expression of developmentally regulated cells during both embryogenesis and oncogenesis.
As a top worldwide antibody supplier, we at Novus Biologicals are constantly extending our antibody database to take advantage of the latest technology and product developments. Recently, we added several embryonic stem cell marker antibodies, conjugated for use in FACS (fluorescence activated cell sorting) assays.
Stem cell marker antibodies are used to identify and isolate stem cells in vitro. Whereas adult stem cells can only differentiate into one cell type, embryonic stem cells (ESCs) have the unique ability to differentiate into a large variety. Stem cells can be genetically manipulated into specific cell lines, and researchers have recently developed a promising new method of producing ESC-like cell lines from adult stem cells.
