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Hypoxia-Dependent CAR Stabilizing Construct in T cells Improves Solid Tumor Targeting and Efficacy

Banner image showing a chimeric antigen receptor (CAR) T cell.

By Victoria Osinski, PhD

Tags: 
Cancer
Chimeric Antigen Receptor
CAR-T
Hypoxia
immunology
Immunotherapy
Oxygen
T Cells
Tumor
Tumor Microenvironment
EGFR
ErbB2/Her2
ErbB3/Her3
ErbB4/Her4
HIF-1 alpha
Victoria Osinski

Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment

Banner image showing cancer cells in hypoxic conditions.

By Hunter Martinez

Tags: 
Adaptive Immunity
Hypoxia
immunology
metabolism
Mitochondria
Oxygen
ROS
T Cells
T cell exhaustion
T cell receptor
Tumor Microenvironment
BLIMP1/PRDM1
CD8
HIF-1 alpha
IFN-gamma
LAG-3
NFAT
NGFI-B alpha/Nur77/NR4A1
PD-1
PGC1 alpha
TIGIT
TNF-alpha
Hunter Martinez

Synthetic Biotic Medicine as Immunotherapy Against Cancer: Evidence From Arginine-Producing Engineered Bacteria

3D banner image showing example of pathogenic bacteria.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Bacteria
Cancer
Cancer Research
Checkpoint Blockade
Checkpoint Inhibitors
immunology
Immuno-oncology
Immunotherapy
Innate Immunity
L-arginine
T Cells
Tumor
ARG-2
CD4
CD8
PD-1
PD-L1
Jamshed Arslan

Immune Cell Metabolic Flux Influences Type I Diabetes

Banner image showing mitochondrion and metabolic pathways and targets, from Tocris.

By Hunter Martinez

Tags: 
Adaptive Immunity
Diabetes
Type I Diabetes
Immunometabolism
Innate Immunity
Macrophage
metabolism
Mitochondria
mTOR Pathway
T Cells
ACSL1
CD4
COX-2
IL-1 beta/IL-1F2
IL-12
IL-18/IL-1F4
Insulin
MHC class II
PGE2
TNF-alpha
Hunter Martinez

Harnessing Natural Killer Cell Activity for Anti-Tumor Immunotherapy

Banner image showing the workflow for Natural Killer (NK) cells.

By Victoria Osinski, PhD

Tags: 
Natural Killer Cell
NK Cell
Cancer
immunology
Immuno-oncology
Immunotherapy
CD8
MHC Class I
NKG2A/CD159a/KLRC1
NKG2C/CD159c/KLRC2
NKG2D/CD314
NKG2E/KLRC3
KLRC4
NKG2H
DAP12
Killer Cell Immunoglobulin-like Receptor
CD7
CD19
Siglec-3/CD33
MUC1
ErbB2/Her2
MICA
MICB
ULBP
HDAC
HLA G
KIR2DL4/CD158d
Victoria Osinski

Understanding ‘Y’ in Breast Cancer: Crucial Role of DNA/RNA-binding Protein YB-1 in the Development, Pre-Invasive, and Metastatic Phases

Akt expression in immersion fixed MDA-MB-231 breast cancer cell line using Mouse Anti-Akt Monoclonal Antibody and stained with NorthernLights 557-conjugated IgG Secondary Antibody.

Jamshed Arslan, Pharm D, PhD

Tags: 
Breast Cancer
Cancer
DNA Repair
YB1
HIF-1 alpha
NRF2
Kras
AKT1
G3BP1
Carbonic Anhydrase IX/CA9
VEGF
CD34
Jamshed Arslan

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents

3D rendering of neuronal induced pluripotent stem cells as a banner image.

Jamshed Arslan, Pharm D, PhD

Tags: 
Dorsal Root Ganglia
Friedreich ataxia
Neuroscience
neurodegeneration
Stem Cells
hPSC
human pluripotent stem cells
iPSCs
Induced Pluripotent Stem Cells
Cell Replacement Therapy
Neurons
Glia
beta-III Tubulin
Calbindin D/S100G
CGRP
EFCBP2
GFAP
GFP
mCherry
NF-H
Osteopontin/OPN
Parvalbumin
Peripherin
Peripherin 2/PRPH 2
Plexin C1
Ret
s100b
Somatostatin
TAFA1/FAM19A1
TrkA
TrkB
TrkC
Tyrosine Hydroxylase
VGluT3
Jamshed Arslan

Taking Biomarker Discovery From 2D to 3D: Increased Biological Activity of EVs Isolated From 3D Prostate Cancer Cultures

3D rendering of extracellular vesicles released from cells as a banner image.

Jamshed Arslan, Pharm D, PhD

Tags: 
Cancer
cell culture
extracellular vesicles
Exosomes
Organoids
Prostate Cancer
Simple Western
PSMA/FOLH1/NAALADase I
CD44
Vimentin
Matrix Metalloproteinase
MMP
MUC1
EGR1
Flotillin-1
GDF-15
Jamshed Arslan

Using CometChip to Characterize Extracellular Regulators of DNA Repair: Does CD73 Levels in Cancer Cells Affect DNA Repair by Regulating Levels of Intracellular NAD+?

3D rendering of CometChip as a banner image.

By Natalia Gurule, PhD

 

Tags: 
Base Excision Repair
Cancer
CometAssay
CometChip
DNA Damage
DNA Repair
Metabolic Signaling
Tumor Microenvironment
TME
5’Nucleotidase/CD73
CD73
Nicotinamide Adenine Dinucleotide
NAD
PARP
Natalia Gurule

Staufen1 Overabundance and the Consequent mTOR Hyperactivity in Amyotrophic Lateral Sclerosis, Spinocerebellar Ataxia Type 2, Alzheimer’s, Parkinson’s, and Huntington’s Diseases

3D rendering of neurons as a banner image.

Jamshed Arslan, Pharm D, PhD

Tags: 
Amyotrophic Lateral Sclerosis
ALS
Spinocerebellar Ataxia Type 2
Alzheimer’s
Parkinson’s
Huntington’s
neurodegeneration
Autophagy
Neurons
Staufen
TOR/mTOR
Jamshed Arslan

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