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COVID-19 and the Cardiovascular System: Observed complications and potential mechanisms

Banner image showing COVID-19 virus with spike protein.

By Victoria Osinski

Tags: 
virology-bacteria-parasite
virus
coronavirus
COVID-19
SARS-CoV-2
Cardiovascular
injury
troponin I
SARS-CoV-2 spike protein
spike protein
ACE-2
tmprss2
Angiotensin II/III
Victoria Osinski

Autophagy and RAS signaling: Clinical implications

Immunocytochemical staining of fixed and permeabilized HeLa cells treated with chloroquine, incubated with LC3B (green) and tubulin (red) antibodies, and counterstained with DAPI to visualized DNA.

By Christina Towers, PhD

Tags: 
Autophagy
Cancer
Pancreatic Ductal Adenocarcinoma
Melanoma
Colorectal Cancer
Ras
LC3B
Beclin 1
mCherry
GFP
NRAS
B-Raf
CA19-9/Sialyl Lewis A
Christina Towers

COVID-19-Related Neurological Problems: Uncovering the Mechanisms

Novus Biologicals 3D image for coronavirus banner

By Jamshed Arslan, Pharm D, PhD

Tags: 
virology-bacteria-parasite
virus
coronavirus
COVID-19
SARS-CoV-2
SARS-CoV-2 spike protein
spike protein
ACE-2
neurodegeneration
Neuroscience
blood brain barrier
immunology
EMMPRIN/CD147
IL-6
IL-10
TNF-alpha
Jamshed Arslan

Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness

Immunohistochemical staining of paraffin-embedded human breast carcinoma with rabbit polyclonal Oct4 antibody.


By Jamshed Arslan, Pharm D, PhD

Tags: 
Breast Cancer
Cancer
Hypoxia
KLF4
NANOG
OCT4
Sox2
S100A10
Annexin A2
HIF-1 alpha
HIF-2 alpha/EPAS1
SPT6
KDM6A
Pluripotency
chemotherapy
Jamshed Arslan

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress

Immunocytochemical staining of formalin-fixed, permeabilized PC12 cells with rabbit polyclonal DRP1 antibody and detected with Dylight 488 (green) and the nuclei counterstained with DAPI (blue).

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
HIV
Human Immunodeficiency Virus
Mitochondria
Mitophagy
ROS
Oxidative Stress
GP120
Tat
Methamphetamine
neurodegeneration
Neurons
LC3B
p62
Autophagy
MAP2
DRP1
Antioxidants
Jamshed Arslan

Deficiency of GluT1 leads to neurological problems while excess is involved in cancers

Immunohistochemical staining of formalin fixed paraffin embedded tissue of human placenta with rabbit polyclonal Glut1 antibody and staining developed using HRP-DAB with hematoxylin counterstaining.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Glucose
GLUT1
galactose
epilepsy
GluT1-deficiency syndrome (GDS)
SLC2A1
Cancer
tubulin 4
glioblastoma
ChREBP
GluT2
Hepatocellular Carcinoma
Jamshed Arslan

Rest in Peace: Is the Receptor Interacting Protein (RIP) Kinase-3 (RIPK3) a Protector or Offender?

RIPK3/RIP3 immunocytochemical staining of fixed HeLa cells with rabbit polyclonal RIPK3/RIP3 antibody (green) and co-stained with an Alpha Tubulin antibody (red).

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
TNF
FasL
TRAIL
DAMPs
RIPK1
RIP3
RIPK3
MLKL
IL-6
CXCL1
CXCL2
CCR2
Jamshed Arslan

Bio-Techne’s CiteAb 2020 Researchers’ Choice Award

Bio-Techne receives CiteAb 2020 Researchers’ Choice Award.

By Kate Wilmore

Tags: 
Bio-Techne
ACD
Tocris
CiteAb
Kate Wilmore

COVID-19 Pathology and Immune Response to SARS-CoV-2 Infection: Highlights from Studies at NIH, CDC, and Harvard

SARS-CoV-2 nucleocapsid protein is found in the core of the viral particle, interacts with viral RNA and functions in genome packing.

By Rosa Moreno, PhD.

Tags: 
Microbiology
virology-bacteria-parasites
virus
SARS-CoV-2 nucleocapsid protein
COVID-19
SARS-CoV-2
ACE-2
Rosa Moreno

Tiny Antibodies (VHHs) from Llama Neutralize Respiratory Coronaviruses

Sharks and llamas produce smaller antibodies called heavy chain-only antibodies (HCAbs) with a single variable domain, VHH.

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
Microbiology
virology-bacteria-parasites
virus
SARS-spike-protein
COVID-19
SARS-CoV-2
ACE-2
sars-cov-2-spike-recombinant-protein
Jamshed Arslan

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