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CD117/c-kit Antibody (104D2) [PE]

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Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB600-765PE
    • Availability
      Product Discontinued

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CD117/c-kit Antibody (104D2) [PE] Summary

Immunogen
Unfortunately, this information is considered to be commercially sensitive
Localization
Type I membrane protein.
Marker
Hematopoietic Stem Cell Marker
Specificity
This recognises the human c-Kit. c-Kit is expressed by some haematopoietic stem cells (approx. 70% of CD34 +ve cells in normal bone marrow are c-Kit +ve), by some acute myeloid leukaemias and by mast cells.This is non-neutralising.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KIT
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence

Reactivity Notes

Cross reacts with Cynomolgus Monkey. Mouse reactivity reported in scientific literature (PMID: 24664884) Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CD117/c-kit Antibody (104D2) [PE]

  • CD117 antigen
  • CD117
  • ckit
  • c-kit
  • EC 2.7.10
  • EC 2.7.10.1
  • KIT
  • PBT
  • piebald trait
  • Proto-oncogene c-Kit
  • proto-oncogene tyrosine-protein kinase Kit
  • SCF R
  • SCFR
  • SCFRmast/stem cell growth factor receptor
  • soluble KIT variant 1
  • Tyrosine-protein kinase Kit
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

Background

CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with it's ligand is critical for the development of hematopoietic stem cells. The 2B8 antibody does not block c-Kit activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CD117/c-kit
Antibody (104D2) [PE]
NB600-765PE
CD117/c-kit Antibody (104D2) [PE]
Species: Hu, Mu, Bv, Pm
Applications: Flow, ICC/IF

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Research Areas for CD117/c-kit Antibody (NB600-765PE)

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Blogs on CD117/c-kit.

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Do you see what I see? I c-Kit
The c-Kit (CD117) proto-oncogene is a 145 kD receptor tyrosine kinase family closely related to platelet-derived growth factor receptor (PDGFR). It is a transmembrane receptor and the cellular homolog of the HZ4-feline sarcoma virus transforming gene ...  Read full blog post.
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Bioinformatics

Gene Symbol KIT