VEGF Antibody [Unconjugated] - 165

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vascular Endothelial Growth Factor (VEGF or VEGF-A), also known as Vascular Permeability Factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. Human VEGF165 is an approximately 44 kDa molecular weight homodimer sharing 88% aa sequence identity with corresponding regions of mouse and rat, 96% with porcine, 95% with canine, and 93% with feline, equine and bovine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells. Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity. VEGF165 binds the Semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2. VEGF is required during embryogenesis and functions to regulate the proliferation, migration, and survival of endothelial cells. In adults, VEGF functions mainly in wound healing and the female reproductive cycle. Pathologically, it is involved in tumor angiogenesis and vascular leakage. Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, Oncostatin M (OSM) and TNF-alpha.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 6 applications: Bioassay, Complex Application, ELISA Development, IHC, IHC-P, Western Blot.

Showing Publications 1 - 10 of 24. Show All 24 Publications. Collapse Publications.

Publications using AB-293-NA	Applications	Species
M Yamakuchi, M Okawa, K Takenouchi, A Bibek, S Yamada, K Inoue, K Higurashi, A Tabaru, K Tanoue, Y Oyama, S Higashi, C Fujisaki, H Kanda, H Terasaki, T Sakamoto, Y Soga, T Hashiguchi VEGF-A165 is the predominant VEGF-A isoform in platelets, while VEGF-A121 is abundant in serum and plasma from healthy individuals PLoS ONE, 2023;18(4):e0284131. 2023 [PMID: 37027444] (ELISA Development, Human)	ELISA Development	Human
M Yamakuchi, M Okawa, K Takenouchi, A Bibek, S Yamada, K Inoue, K Higurashi, A Tabaru, K Tanoue, Y Oyama, S Higashi, C Fujisaki, H Kanda, H Terasaki, T Sakamoto, Y Soga, T Hashiguchi VEGF-A165 is the predominant VEGF-A isoform in platelets, while VEGF-A121 is abundant in serum and plasma from healthy individuals PLoS ONE, 2023-04-07;18(4):e0284131. 2023-04-07 [PMID: 37027444] (ELISA Development, Human)	ELISA Development	Human
Pamela J. Maxwell, Melanie McKechnie, Christopher W. Armstrong, Judith M. Manley, Chee Wee Ong, Jenny Worthington et al. Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers Molecular Cancer Research 6/3/2022 [PMID: 35302608]
Olachi J. Mezu-Ndubuisi, Yong-Seok Song, Erica Macke, Hailey Johnson, Ginika Nwaba, Akihiro Ikeda et al. Retinopathy of prematurity shows alterations in Vegfa164 isoform expression Pediatric Research 6/1/2022 [PMID: 34285351]
Y Wu, H Zhang, M Tang, C Guo, A Deng, J Li, Y Wang, L Xiao, G Yang High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis J Transl Med, 2020-05-24;18(1):210. 2020-05-24 [PMID: 32448279] (Western Blot, Human)	Western Blot	Human
T Xiang, YX Lin, W Ma, HJ Zhang, KM Chen, GP He, X Zhang, M Xu, QS Feng, MY Chen, MS Zeng, YX Zeng, L Feng Vasculogenic mimicry formation in EBV-associated epithelial malignancies Nat Commun, 2018-11-27;9(1):5009. 2018-11-27 [PMID: 30479336] (Bioassay, Human)	Bioassay	Human
İbrahim Deniz Canbeyli, Rahmi Can Akgun, Orcun Sahin, Aysen Terzi, İsmail Cengiz Tuncay Platelet-rich plasma decreases fibroblastic activity and woven bone formation with no significant immunohistochemical effect on long-bone healing: An experimental animal study with radiological outcomes J Orthop Surg (Hong Kong) 10/9/2018 [PMID: 30295139]
Gamze Tan, Karsten Kantner, Qian Zhang, Mahmoud G. Soliman, Pablo del Pino, Wolfgang J. Parak et al. Conjugation of Polymer-Coated Gold Nanoparticles with Antibodies—Synthesis and Characterization Nanomaterials (Basel) 8/7/2015 [PMID: 28347065]
AM Kivelä, J Huusko, E Gurzeler, A Laine, MH Dijkstra, G Dragneva, CB Andersen, SK Moestrup, S Ylä-Herttu High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy Sci Rep, 2017-03-24;7(1):386. 2017-03-24 [PMID: 28341860] (IHC, Mouse)	IHC	Mouse
Manuel D. Gahete, David Rincón-Fernández, Mario Durán-Prado, Marta Hergueta-Redondo, Alejandro Ibáñez-Costa, Alejandro Rojo-Sebastián et al. The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients Oncotarget 9/13/2016 [PMID: 27507050]
Leonardo Rojas‐Puentes, Andrés F. Cardona, Hernán Carranza, Carlos Vargas, Luis F. Jaramillo, Delma Zea et al. Epithelial–mesenchymal transition, proliferation, and angiogenesis in locally advanced cervical cancer treated with chemoradiotherapy Cancer Medicine 8/1/2016 [PMID: 27230280]
Lewin J, Khamly K, Young R, Mitchell C, Hicks R, Toner G, Ngan S, Chander S, Powell G, Herschtal A, Te Marvelde L, Desai J, Choong P, Stacker S, Achen M, Ferris N, Fox S, Slavin J, Thomas D A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma. Br J Cancer, 2014-10-16;111(12):2254-61. 2014-10-16 [PMID: 25321190] (IHC, Human)	IHC	Human
Julia Litvinov, Anna E. V. Hagström, Yubitza Lopez, Meenu Adhikari, Katerina Kourentzi, Ulrich Strych et al. Ultrasensitive immuno-detection using viral nanoparticles with modular assembly using genetically-directed biotinylation Biotechnology Letters 9/1/2014 [PMID: 24930095]
Pound L, Comstock S, Grove K Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese macaque model. Am J Physiol Endocrinol Metab, 2014-05-20;307(1):E115-23. 2014-05-20 [PMID: 24844258] (IHC-P, Primate - Macaca mulatta (Rhesus Macaque))	IHC-P	Primate - Macaca mulatta (Rhesus Macaque)
Kondo S, Mukudai Y, Soga D, Nishida T, Takigawa M, Shirota T Differential expression of vascular endothelial growth factor in high- and low-metastasis cell lines of salivary gland adenoid cystic carcinoma. Anticancer Res, 2014-02-01;34(2):671-7. 2014-02-01 [PMID: 24510998] (Western Blot, Human)	Western Blot	Human
Hakroush S, Cebulla A, Schaldecker T, Behr D, Mundel P, Weins A Extensive podocyte loss triggers a rapid parietal epithelial cell response. J Am Soc Nephrol, 2013-12-12;25(5):927-38. 2013-12-12 [PMID: 24335975] (IHC, Human)	IHC	Human
Bernard Y.K. Binder, Damian C. Genetos, J. Kent Leach Lysophosphatidic Acid Protects Human Mesenchymal Stromal Cells from Differentiation-Dependent Vulnerability to Apoptosis Tissue Engineering Part A 4/1/2014 [PMID: 24131310]
Jiawei He, Martin L. Decaris, J. Kent Leach Bioceramic-mediated trophic factor secretion by mesenchymal stem cells enhances in vitro endothelial cell persistence and in vivo angiogenesis Tissue Engineering Part A 7/1/2012 [PMID: 22546052]
Allison I. Hoch, Bernard Y. Binder, Damian C. Genetos, J. Kent Leach Differentiation-Dependent Secretion of Proangiogenic Factors by Mesenchymal Stem Cells PLoS ONE 4/20/2012 [PMID: 22536411]
Uniewicz KA, Cross MJ, Fernig DG Exogenous recombinant dimeric neuropilin-1 is sufficient to drive angiogenesis. J. Biol. Chem., 2010-10-18;286(1):12-23. 2010-10-18 [PMID: 20956519] (Complex Application, Human)	Complex Application	Human
William W. Yuen, Nan R. Du, Chun H. Chan, Eduardo A. Silva, David J. Mooney Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones Proceedings of the National Academy of Sciences 10/19/2010 [PMID: 20921366]
Guangheng Li, Karin Corsi-Payne, Bo Zheng, Arvydas Usas, Hairong Peng, Johnny Huard The Dose of Growth Factors Influences the Synergistic Effect of Vascular Endothelial Growth Factor on Bone Morphogenetic Protein 4–Induced Ectopic Bone Formation Tissue Engineering Part A 2/19/2010 [PMID: 19215221]
Nicoletti JN, Shah SK, McCloskey DP, Goodman JH, Elkady A, Atassi H, Hylton D, Rudge JS, Scharfman HE, Croll SD Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience, 2007-10-26;151(1):232-41. 2007-10-26 [PMID: 18065154] (ELISA Development, IHC, Rat)	ELISA Development, IHC	Rat
Carlile J, 2019, Harada K, Baillie R, Macluskey M, Chisholm DM, Ogden GR, Schor SL, Schor AM Vascular endothelial growth factor (VEGF) expression in oral tissues: possible relevance to angiogenesis, tumour progression and field cancerisation. 653-664, 2001-09-01;30(8):449-57. 2001-09-01 [PMID: 11545235] (IHC-P, Human)	IHC-P	Human
Show All 24 Publications. Collapse Publications.

Array AB-293-NA

• VEGF Antibodies
• VEGF ELISA Kits
• VEGF Lysates
• VEGF Proteins
• VEGF Proteins and Enzymes
• VEGF ELISAs