UBR5/EDD Antibody

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. EDD1 has also been shown to associate with Chk2 and is necessary for the efficient phosphorylation and activation of Chk2 in response to DNA damage.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IHC-P, KD, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-1591	Applications	Species
Xiaojing Ma, Ziqi Yu, Xue D et al. Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing apoptosis mediated by CDC73 and p53 Research Square 2022-11-29 (IHC-P, Human)	IHC-P	Human
Yu Z, Dong X, Song M et al. Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis International journal of cancer 2023-10-19 [PMID: 37855385]
Wang C, Hong T, Wang Y et al. Combining UBR5 and CD163+ tumor-associated macrophages better predicts prognosis of clear cell renal cell carcinoma patients Cancer immunology, immunotherapy : CII 2021-03-12 [PMID: 33710368]
Bian P, Dou Z, Jia Z et al. Activated Wnt/beta-Catenin signaling contributes to E3 ubiquitin ligase EDD-conferred docetaxel resistance in prostate cancer Life Sci. 2019-08-28 [PMID: 31472148] (IHC-P, KD, WB, Mouse, Human)	IHC-P, KD, WB	Mouse, Human
Metzig MO, Fuchs D, Tagscherer KE, Grone HJ. Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-a-dependent necroptosis driven by RIP1 kinase and NF-kB. Oncogene. 2015-11-02 [PMID: 26522725] (WB, Human)	WB	Human
Christofferson DE, Li Y, Hitomi J et al. A novel role for RIP1 kinase in mediating TNF? production Cell Death Dis 2012-06-14 [PMID: 22695613] (WB, Human)	WB	Human
Odagiri S, Tanji K, Mori F et al. Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin-proteasome system, autophagy and aggresome formation. Neuropathology 2012-06-01 [PMID: 22118216]
Dompe N, Rivers CS, Li L et al. A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2011-09-26 [PMID: 21949371]
Ling S, Lin WC. EDD inhibits ATM-mediated phosphorylation of p53. J Biol Chem 2011-04-01 [PMID: 21383020]
O'Brien PM, Davies MJ, Scurry JP et al. The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro. Br J Cancer 2008-03-01 [PMID: 18349819]

Array NB100-1591

• UBR5/EDD Antibodies
• UBR5/EDD Protein