Western Blot: TSLP Antibody (55N1D10) [NBP2-27326] - Analysis of a TSLP recombinant protein using TSLP antibody. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: TSLP Antibody (55N1D10) [NBP2-27326] - FFPE normal human spleen (top) and human lung carcinoma (bottom) stained with TSLP antibody, peroxidase-conjugate and DAB chromogen.
Rabbit reactivity reported in scientific literature (PMID: 31925326).
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified
Alternate Names for TSLP Antibody (55N1D10) - BSA Free
thymic stromal lymphopoietin
TSLP
Background
TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of Tcell-attracting chemokines from monocytes, enhances the maturation of CD11c+ dendritic cells, naive CD4+, and CD8+ Tcells into proallergic effectors, and primes DCs to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory Tcells and maintenance of peripheral CD4+ Tcell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. TSLP is expressed in heart, liver and prostate.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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