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TSLP Antibody (152614)

 (25 Publications)
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Recombinant Mouse TSLP (Catalog # 555-TS) stimulates proliferation in the BaF3 mouse pro‑B cell line transfected with mouse IL‑7 R alpha in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse TSLP (7.5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse TSLP Monoclonal Antibody (Catalog # MAB555). The ND50 is typically 0.1-0.4 µg/mL.
Recombinant Mouse TSLP (Catalog # 555-TS) stimulates proliferation in the BaF3 mouse pro‑B cell line transfected with mouse IL‑7 R alpha in a dose-dependent manner (orange line). Proliferation ...read more
TSLP neutralization inhibits airway structural alterations.(A) The depth of peribronchial collagen deposition was significantly reduced in anti-TSLP-treated mice, compared with HDM-exposed and IgG isotype-treated ...read more
TSLP neutralization inhibits surface marker expression on airway CD11c+ cells.(A) Lung cell suspensions from mice were stained with combinations of PerCP-Cy 5.5-conjugated CD11c, PE-conjugated OX40L, FITC-conjugated ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, B/N
Clone
152614
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
MAB555-SP
Carrier Free
MAB555-500
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TSLP Antibody (152614) Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TSLP
Tyr20-Glu140
Accession # Q9JIE6
Specificity
Detects mouse TSLP in Western blots.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TSLP
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Neutralization 0.1-0.4 ug/mL
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB555 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TSLP Antibody (152614)

  • thymic stromal lymphopoietin
  • TSLP

Background

TSLP is an IL-7 related cytokine secreted by multiple tissues. It interacts with the heterodimeric receptor complex consisting of IL-7 R alpha and TSLP R. Mouse TSLP stimulates the growth of thymocytes and mature T cells and also supports B cell lymphopoiesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TSLP Antibody (MAB555)(25)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 6 applications: Flow Cytometry, ICC, IHC, In Vivo, Neutralization, Neutralizing.


Filter By Application
Flow Cytometry
(1)
ICC
(1)
IHC
(1)
In Vivo
(3)
Neutralization
(14)
Neutralizing
(1)
All Applications
Filter By Species
Mouse
(21)
All Species
Showing Publications 1 - 10 of 25. Show All 25 Publications.
Publications using MAB555 Applications Species
D Sacks, SH Lee, B Kang, O Kamenyeva, T Ferreira, K Cho, J Khillan, J Kabat, B Kelsall Dermis resident macrophages orchestrate localized ILC2-eosinophil circuitries to maintain their M2-like properties and promote non-healing cutaneous leishmaniasis Research square, 2023-04-05;0(0):. 2023-04-05 [PMID: 37066418] (Neutralization, Mouse) Neutralization Mouse
Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn&#039;s disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (In Vivo, Mouse) In Vivo Mouse
W Yao, B German, D Chraa, A Braud, C Hugel, P Meyer, G Davidson, P Laurette, G Mengus, E Flatter, P Marschall, J Segaud, M Guivarch, P Hener, MC Birling, D Lipsker, I Davidson, M Li Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment JCI Insight, 2022-11-08;0(0):. 2022-11-08 [PMID: 36107619] (Neutralization, Mouse) Neutralization Mouse
Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su Eosinophil extracellular traps drive asthma progression through neuro-immune signals Nature Cell Biology, 2021-10-06;23(10):1060-1072. 2021-10-06 [PMID: 34616019] (In Vivo, Mouse) In Vivo Mouse
N Majumder, WT Goldsmith, VK Kodali, M Velayutham, SA Friend, VV Khramtsov, TR Nurkiewicz, A Erdely, PC Zeidler-Er, V Castranova, JR Harkema, EE Kelley, S Hussain Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure Redox Biology, 2021-08-05;46(0):102092. 2021-08-05 [PMID: 34418598] (Neutralization, Mouse) Neutralization Mouse
Hea Yon Lee, Hwa Young Lee, Jung Hur, Hye Seon Kang, Joon Young Choi, Chin Kook Rhee et al. Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma The Korean Journal of Internal Medicine 2020-05-01 [PMID: 32183504]
S Li, Z Yi, M Deng, MJ Scott, C Yang, W Li, Z Lei, NM Santerre, P Loughran, TR Billiar TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway JCI Insight, 2019-11-14;4(22):. 2019-11-14 [PMID: 31723054] (Mouse) Mouse
NR Han, PD Moon, HM Kim, HJ Jeong TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway J Clin Med, 2019-09-01;8(9):. 2019-09-01 [PMID: 31480519] (Neutralizing, Mouse) Neutralizing Mouse
Sheng-Chieh Lin, Hsiu-Chu Chou, Chung-Ming Chen, Bor-Luen Chiang Anti-thymic stromal lymphopoietin antibody suppresses airway remodeling in asthma through reduction of MMP and CTGF Pediatric Research 2019-08-01 [PMID: 30464333]
Verma M, Liu S, Michalec L, Sripada A, Gorska M, Alam R Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9&lt;sup&gt;+&lt;/sup&gt; and IL-13&lt;sup&gt;+&lt;/sup&gt; type 2 innate lymphoid cell subpopulations. J Allergy Clin Immunol, 2017-11-10;0(0):. 2017-11-10 [PMID: 29132961] (Neutralization, Mouse) Neutralization Mouse
Show All 25 Publications.

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Bioinformatics

Gene Symbol TSLP
Uniprot