TRPM2 Antibody - BSA Free

TRP7 (transient receptor protein 7 or TRPC7) is the seventh identified member of mammalian TRPC channel family which includes nonselective cation channels that mediate changes in plasma membrane cation permeability induced by stimulation of PLC (phospholipase C, the cellular integrator that receives input from GPCRs/ RTK). Major cellular function of TRPC channels is to regulate Ca2+ influx across plasma membrane induced by stimulation of these receptors by hormones, neurotransmitters, and growth factors. Localized in the cell membrane and nuclear envelope as multi-pass membrane protein, TRPC7 interacts with with MX1, RNF24, PRKG1 etc. and PRKG1 mediated TRPC7 phosphorylation at Thr-15 site negatively regulates TRPC7's activity. TRP7 has been suggested to form a receptor-activated non-selective calcium permeant cation channel and is operated by a phosphatidylinositol second messenger system activated by RTKs or GPCRs. TRP7 is activated by DAG (diacylglycerol) and also upon intracellular calcium store depletion.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using NB110-81601	Applications	Species
Rah SY, Joe Y, Park J et al. CD38/ADP-ribose/TRPM2-mediated nuclear Ca2+ signaling is essential for hepatic gluconeogenesis in fasting and diabetes Experimental & molecular medicine 2023-07-01 [PMID: 37394593] (ICC/IF, Mouse)	ICC/IF	Mouse
Chiaki Yoshikawa, Hiroharu Maegawa, Nayuka Usami, Hiroshi Hanamoto, Chiho Kudo, Hitoshi Niwa Antagonist of transient receptor potential melastatin 2 suppresses mechanical hypersensitivity and activation of microglia induced by infraorbital nerve ligation in male rats. Biochemical and biophysical research communications 2023-07-18 [PMID: 37295356]
Zong P, Feng J, Yue Z et al. TRPM2 deficiency in mice protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages Nature Cardiovascular Research 2022-04-21 [PMID: 35445217]
Zong P, Feng J, Yue Z et al. Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury Neuron [PMID: 35421327]
Wang W, Yang Q, Zhou C et al. Transcriptomic changes in the hypothalamus of ovariectomized mice: Data from RNA-seq analysis Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2022-01-12 [PMID: 35032566] (IF/IHC, Mouse)	IF/IHC	Mouse
Yee AG, Freestone PS, Bai JZ, Lipski J Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone. Exp. Neurol. 2016-10-19 [PMID: 27771354] (IF/IHC)	IF/IHC
Rah SY, Kwak JY, Chung YJ, Kim UH ADP-ribose/TRPM2-mediated Ca2+) signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. Sci Rep 2015-03-25 [PMID: 25879940] (ICC/IF, Mouse) Details: This publication used the DL550 conjugated form of this antibody (NB110-81601R)	ICC/IF	Mouse
Chung MK, Asgar J, Lee J et al. The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia Neuroscience 2015-04-04 [PMID: 25849615] (WB, Rat)	WB	Rat
Lu S, Xiang L, Clemmer JS et al. Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 (TRPM2) channels. Microcirculation 2014-07-24 [PMID: 25059284] (WB, Rat) Details: TRPM2 antibody used for WB on tissue lysate of pulmonary arteries from control male lean Zucker/LZ Rats and hyperglycemic LZ rats (streptozotocin/STZ 50mg/kg -induced type I diabetic model). Figure 1 shows the down-regulation of TRPM2-L channel in STZ-treated type I diabetic LZ.	WB	Rat
Roberge S, Roussel J, Andersson DC et al. TNF-alpha-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes. Cardiovasc. Res. 2014-05-06 [PMID: 24802330] (WB, Mouse)	WB	Mouse
Melzer N, Hicking G, Gobel K, Wiendl H. TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation PLoS One 2012-01-01 [PMID: 23077651] (ICC/IF, Mouse)	ICC/IF	Mouse
Chung KK, Freestone PS, Lipski J. Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol;106(6):2865-75. 2011-12-01 [PMID: 21900507] (IF/IHC, Rat)	IF/IHC	Rat
Bai JZ, Lipski J. Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Neurotoxicology. 2010-01-12 [PMID: 20064552] (ICC/IF, WB, Rat)	ICC/IF, WB	Rat
Show All 13 Publications. Collapse Publications.

Array NB110-81601

• TRPM2 Antibodies
• TRPM2 Proteins