TRPM4 Antibody (OTI10H5)

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	IHC-P	Human	12/13/2021	View Summary Application Immunohistochemistry-Paraffin Sample Tested Endometrial carcinoma Species Human Lot OTI10H5 Comments Comments Fixed paraffin embedded sections were deparaffinized. EDTA was used for antigen retrieval. Samples were incubated O/N in 4 C with the primary antibody (1:200 dilution).
	5 reviewed by: Verified Customer	IHC/Immunofluorescence	Human	08/27/2021	View Summary Application Other Sample Tested Heart tissue Species Human Lot OTI10H5

Array NBP1-48036

• TRPM4 Antibodies
• TRPM4 Lysate
• TRPM4 Protein