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Tripeptidyl-Peptidase I/TPP1 Antibody (S09-2G9)

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Western Blot: Tripeptidyl-Peptidase I/TPP1 Antibody (S09-2G9) [NBP3-15105] - Western blot detection of Tripeptidyl-Peptidase I/TPP1 in Hela, Jurkat, HepG2 cell lysates using Tripeptidyl-Peptidase I/TPP1 Rabbit mAb ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clone
S09-2G9
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Tripeptidyl-Peptidase I/TPP1 Antibody (S09-2G9) Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant protein of human Tripeptidyl-Peptidase I/TPP1 (Uniprot#: O14773)
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
TPP1
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1/1000-1/2000

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium Azide
Purity
Affinity purified

Alternate Names for Tripeptidyl-Peptidase I/TPP1 Antibody (S09-2G9)

  • Cell growth-inhibiting gene 1 protein
  • ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease)
  • CLN2
  • CLN2EC 3.4.14.9
  • growth-inhibiting protein 1
  • LINCL
  • LPIC
  • lysosomal pepstatin insensitive protease
  • Lysosomal pepstatin-insensitive protease
  • MGC21297
  • TPP1
  • TPP-1
  • TPP-I
  • Tripeptidyl aminopeptidase
  • tripeptidyl peptidase I
  • tripeptidyl-peptidase 1
  • TripeptidylPeptidase I
  • Tripeptidyl-Peptidase I

Background

TPP1 encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TPP1